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Literature DB >> 6167874

Postmortem changes of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in mouse brain and their prevention by pargyline and microwave irradiation.

Abstract

Postmortem (pm) manipulations of brain tissue of decapitated mice produced a maximum decline in 5-HT and a maximum rise in 5-HIAA of 20 and 40%, respectively. The pm treatments included freezing and thawing, mincing, and leaving over. Microwave irradiation or pretreatment of the animals with the enzymatic inhibitors NSD 1015 or pargyline suppressed the pm effects. The possible role of pm effects in the initial accumulation of 5-HT and decline of 5-HIAA in the brain following administration of pargyline was studied. Out data suggest that, when MAO inhibitors are used, 5-HT turnover might be overestimated by pm changes.

Entities: Chemical Disease Species

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Year: 1981 PMID： 6167874 DOI： 10.1007/BF00963857

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

17 in total

1. Central monoamines and the death process time (antemortem time) during asphyxia. An experimental study in the mouse brain.

Authors: K Yoshimoto; Y Irizawa; N Itoh; Y Hashimoto; S Komura
Journal: Z Rechtsmed Date: 1984

1 in total

Postmortem changes of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in mouse brain and their prevention by pargyline and microwave irradiation.

1. Changes in the 5-hydroxytryptamine content of rat, rabbit and human brain after death.

2. Postmortem stability of norepinephrine, dopamine, and serotonin in rat brain.

3. A semiautomated fluorometric determination of 5-hydroxyindoles in the nanogram range.

4. Dissociation of morphine tolerance and dependence from brain serotonin synthesis rate in mice.

5. Brain serotonin metabolism in isolated aggressive mice.

6. Differences in brain area 5-hydroxytryptamine turnover and rearing behavior in rats and mice of both sexes.

7. Forebrain freezing rates and substrate levels in decapitated rat heads.

8. Brain serotonin turnover in morphine tolerant and dependent mice.

9. In-vivo measurements of tryptophan and tyrosine hydroxylase activities in mouse brain.

10. Estimation of the rate of 5-HT synthesis in the mouse brain by various methods.

1. Central monoamines and the death process time (antemortem time) during asphyxia. An experimental study in the mouse brain.