Literature DB >> 6166720

Presence of interchain disulfide bonds between two gene products that compose the secreted form of an antigen-specific suppressor factor.

M Taniguchi, T Saito, I Takei, T Tokuhisa.   

Abstract

The secreted form of the suppressor T cell factor specific for keyhole limpet hemocyanin derived from the hybridoma 34S-704 was found to consist of the two distinct polypeptide chains, i.e., the antigen-binding and the I-J-encoded chains. They were linked in covalent association with disulfide bonds. The two chains were cleaved by the reduction with dithiothreitol and were easy to reconstitute the active form of TsF. The association of the two distinct chains was suggested to be essential for the expression of the TsF activity.

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Year:  1981        PMID： 6166720      PMCID： PMC2186189          DOI： 10.1084/jem.153.6.1672

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  15 in total

1.  T-cell lines producing antigen-specific suppressor factor.

Authors:  S Kontiainen; E Simpson; E Bohrer; P C Beverley; L A Herzenberg; W C Fitzpatrick; P Vogt; A Torano; I F McKenzie; M Feldmann
Journal:  Nature       Date:  1978-08-03       Impact factor: 49.962

2.  The covalent structure of a human gamma G-immunoglobulin. IV. The interchain disulfide bonds.

Authors:  W E Gall; B A Cunningham; M J Waxdal; W H Konigsberg; G M Edelman
Journal:  Biochemistry       Date:  1968-05       Impact factor: 3.162

3.  Antigen-specific suppressive factor produced by a transplantable I-J bearing T-cell hybridoma.

Authors:  M Taniguchi; T Saito; T Tada
Journal:  Nature       Date:  1979-04-05       Impact factor: 49.962

4.  An antigen-specific I region gene product that augments the antibody response.

Authors:  T Tokuhisa; M Taniguchi; K Okumura; T Tada
Journal:  J Immunol       Date:  1978-02       Impact factor: 5.422

5.  Chemical coupling of peptides and proteins to polysaccharides by means of cyanogen halides.

Authors:  R Axén; J Porath; S Ernback
Journal:  Nature       Date:  1967-06-24       Impact factor: 49.962

6.  Immunosuppressive factor(s) specific for L-glutamic acid50-L-tyosine50. IV. In vitro activity and immunochemical properties.

Authors:  J Thèze; C Waltenbaugh; R N Germain; B Benacerraf
Journal:  Eur J Immunol       Date:  1977-10       Impact factor: 5.532

7.  Enrichment of specific suppressor T cells and characterization of their surface markers.

Authors:  M Taniguchi; J F Miller
Journal:  J Exp Med       Date:  1977-11-01       Impact factor: 14.307

8.  Shared idiotypic determinants on antibodies and T-cell-derived suppressor factor specific for the random terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10.

Authors:  R N Germain; S T Ju; T J Kipps; B Benacerraf; M E Dorf
Journal:  J Exp Med       Date:  1979-03-01       Impact factor: 14.307

9.  Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex.

Authors:  T Tada; M Taniguchi; C S David
Journal:  J Exp Med       Date:  1976-09-01       Impact factor: 14.307

10.  Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate across allogeneic barriers.

Authors:  M J Taussig; A J Munro; R Campbell; C S David; N A Staines
Journal:  J Exp Med       Date:  1975-09-01       Impact factor: 14.307
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  27 in total

Review 1.  Special regulatory T-cell review: A rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm.

Authors:  Ronald N Germain
Journal:  Immunology       Date:  2008-01       Impact factor: 7.397

2.  Two-chain disulphide-bonded structure of antigen-specific T-helper factor: both chains are necessary for activity and their interaction is I-A restricted.

Authors:  J A Little; G L Asherson; V Colizzi; B M James; T Hraba
Journal:  Immunology       Date:  1985-08       Impact factor: 7.397

Review 3.  Antigen-specific suppressor factor: missing pieces in the puzzle.

Authors:  R M O'Hara
Journal:  Immunol Res       Date:  1995       Impact factor: 2.829

4.  Formal proof that different-size Lyt-2 polypeptides arise from differential splicing and post-transcriptional regulation.

Authors:  M Tagawa; H Nakauchi; L A Herzenberg; G P Nolan
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

5.  Characterization of a Db-specific helper factor required for the induction of cytotoxic responses to alloantigens with the use of monoclonal antibodies specific for the helper factor or the T-cell antigen receptor.

Authors:  P C Kwong; H S Teh
Journal:  Immunology       Date:  1987-06       Impact factor: 7.397

6.  The use of a monoclonal i-j-specific antibody to distinguish cells in the feedback suppression circuit from those in the contrasuppressor circuit.

Authors:  K Yamauchi; M Taniguchi; D Green; R K Gershon
Journal:  Immunogenetics       Date:  1982       Impact factor: 2.846

7.  Structural analysis of antigen-specific Ia-bearing regulatory T-cell factors: gel electrophoretic analysis of the antigen-specific augmenting T -cell factor.

Authors:  S Miyatani; K Hiramatsu; P B Nakajima; F L Owen; T Tada
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

Review 8.  Structure of antigen-specific suppressor factors: current views.

Authors:  S K Kontiainen; R F James; E J Culbert; M Feldmann
Journal:  Surv Immunol Res       Date:  1982

9.  Partial purification and characterization of an antigen-specific helper factor synthesized by a T-cell continuous line.

Authors:  R Lifshitz; R N Apte; E Mozes
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

10.  Diffusible suppressor factor from splenic macrophages in murine plasmacytoma.

Authors:  Y H Chen; P Heller
Journal:  Clin Exp Immunol       Date:  1984-07       Impact factor: 4.330
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