| Literature DB >> 6166164 |
K Saeki, S Seo, M Murakami, I Ikehara.
Abstract
Histamine and 4-methylhistamine increased on cyclic AMP level in chopped guinea-pig submandibular glands. 4-Methylhistamine was more active than histamine. 2-(2-Pyridyl)ethylamine was less active than histamine or almost inactive. Metiamide markedly antagonized the histamine-induced cyclic AMP increase but mepyramine had no inhibitory effect on this increase. These results suggest that there are H2-receptors which mediate the cyclic AMP response to histamine in the guinea-pig submandibular gland.Entities:
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Year: 1981 PMID: 6166164 DOI: 10.1007/BF01991487
Source DB: PubMed Journal: Agents Actions ISSN: 0065-4299