Literature DB >> 6165994

Positive selection of major histocompatibility complex-restricted suppressor T cells bearing the predominant idiotype in the immune response to lysozyme.

B A Araneo, R L Yowell, D W Metzger, E E Sercarz.   

Abstract

The lysozyme system provides an excellent model for studying the role of multiple major histocompatibility complex (MHC) genes in the induction and regulation of Ir-gene controlled immune responses. Immunization of H-2b mice leads to concomitant activation of helper and suppressor activities by different epitopes on hen egg-white lysozyme (HEL) and thus phenotype unresponsiveness to native HEL. HEL-specific suppressor T cells in C57BL/10 nonresponder mice show MHC restriction, because their enrichment on antigen-pulsed macrophage monolayers requires syngeneic macrophages as well as HEL. The expression of the selected suppressor function requires interaction between the restricted suppressor precursor cell and an HEL-triggered, suppressor-inducer T cell. The MHC-restricted suppressor precursors bear the predominant idiotype found on anti-HEL antibodies, whereas MHC-restricted helpers do not.

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Year:  1981        PMID： 6165994      PMCID： PMC319081          DOI： 10.1073/pnas.78.1.499

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  37 in total

1.  Ir gene defects may reflect a regulatory imbalance. I. Helper T cell activity revealed in a strain whose lack of response is controlled by suppression.

Authors:  B A Araneo; R L Yowell; E E Sercarz
Journal:  J Immunol       Date:  1979-09       Impact factor: 5.422

2.  In vitro evidence from anti-hapten antibody responses for T helper and suppressor cells directed against major histocompatibility antigens in the mouse. Participation of I region determinants in the induction of T helper cells.

Authors:  P Vogt; E Simpson
Journal:  Eur J Immunol       Date:  1979-07       Impact factor: 5.532

3.  The fundamental T cell proliferative repertoire in a nonresponder strain and its qualitative alteration by suppression.

Authors:  R L Yowell; B A Araneo; E E Sercarz
Journal:  J Immunol       Date:  1980-05       Impact factor: 5.422

4.  The fine specificity of regulatory T cells. I. Hen egg-white lysozyme-induced suppressor T cells in a genetically nonresponder mouse strain do not recognize a closely related immunogenic lysozyme.

Authors:  L Adorini; A Miller; E E Sercarz
Journal:  J Immunol       Date:  1979-03       Impact factor: 5.422

5.  Lysozyme-induced T-suppressor cells and antibodies have a predominant idiotype.

Authors:  M A Harvey; L Adorini; A Miller; E E Sercarz
Journal:  Nature       Date:  1979-10-18       Impact factor: 49.962

6.  A predominant idiotype on anti-hen egg white lysozyme antibodies from diverse mouses strains.

Authors:  C D Benjamin; A Miller; E E Sercarz; M A Harvey
Journal:  J Immunol       Date:  1980-09       Impact factor: 5.422

7.  Genetic control of immunoregulatory circuits. Genes linked to the Ig locus govern communication between regulatory T-cell sets.

Authors:  D D Eardley; F W Shen; H Cantor; R K Gershon
Journal:  J Exp Med       Date:  1979-07-01       Impact factor: 14.307

8.  Immunization of dissociated spleen cell cultures from normal mice.

Authors:  R I Mishell; R W Dutton
Journal:  J Exp Med       Date:  1967-09-01       Impact factor: 14.307

9.  Suppressor T-cell mechanisms in contact sensitivity. III. Apparent non-major histocompatibility complex restriction is a result of multiple sets of major histocompatibility complex-specific suppressor T cells induced by syngeneic 2,4-dinitrophenyl-modified lymphoid cells.

Authors:  S D Miller
Journal:  J Exp Med       Date:  1979-09-19       Impact factor: 14.307

10.  Fine specificity of regulatory T cells. II. Suppressor and helper T cells are induced by different regions of hen egg-white lysozyme in a genetically nonresponder mouse strain.

Authors:  L Adorini; M A Harvey; A Miller; E E Sercarz
Journal:  J Exp Med       Date:  1979-08-01       Impact factor: 14.307
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  3 in total

Review 1.  Coexistence of immunogenic and suppressogenic epitopes in tumor cells and various types of macromolecules.

Authors:  D Naor
Journal:  Cancer Immunol Immunother       Date:  1983       Impact factor: 6.968

2.  Complementation of allotype- and nonallotype-linked genes in the induction of low-zone tolerance to phage fd.

Authors:  J Heuer; E Kölsch
Journal:  Immunogenetics       Date:  1981       Impact factor: 2.846

3.  Immune response genes controlling responsiveness to major transplantation antigens. Specific major histocompatibility complex-linked defect for antibody responses to class I alloantigens.

Authors:  G W Butcher; J R Corvalán; D R Licence; J C Howard
Journal:  J Exp Med       Date:  1982-01-01       Impact factor: 14.307
  3 in total

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