| Literature DB >> 6165572 |
E A Crandall, M A Gillis, J D Fernstrom.
Abstract
The rate of serotonin synthesis in brain was determined in streptozotocin-diabetic and normal rats using two methods. Both the rate of 5-hydroxytryptophan accumulation after aromatic amino acid decarboxylase inhibition, and the decline rate of 5-hydroxyindole acetic acid after pargyline treatment were significantly reduced in diabetic rats. The reduced rate of synthesis may be a direct result of significantly lowered brain tryptophan levels in diabetic rats.Entities:
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Year: 1981 PMID： 6165572 DOI： 10.1210/endo-109-1-310
Source DB: PubMed Journal: Endocrinology ISSN： 0013-7227 Impact factor: 4.736