Literature DB >> 6165445

Substance P decreases a potassium conductance of spinal cord neurons in cell culture.

L M Nowak, R L MacDonald.   

Abstract

Substance P (SP) produced membrane depolarization and decreased membrane conductance of mouse spinal cord neurons in primary dissociated cell culture. SP-responses were abolished by intracellular tetraethylammonium suggesting that SP decreased potassium conductance. Reversal of SP-responses was not observed with membrane hyperpolarization suggesting that SP reduced a voltage-dependent potassium conductance that was activated by membrane depolarization.

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Year:  1981        PMID： 6165445     DOI： 10.1016/0006-8993(81)91205-1

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  5 in total

1.  Spinal neurons exhibiting a specific nociceptive response receive abundant substance P-containing synaptic contacts.

Authors:  Y De Koninck; A Ribeiro-da-Silva; J L Henry; A C Cuello
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205

2.  Dissociated cell culture of cholinergic neurons from nucleus basalis of Meynert and other basal forebrain nuclei.

Authors:  Y Nakajima; S Nakajima; K Obata; C G Carlson; K Yamaguchi
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

3.  Inhibition by substance P of some peripheral actions of acetylcholine in the cat.

Authors:  S L Clark; R W Ryall
Journal:  Br J Pharmacol       Date:  1982-08       Impact factor: 8.739

4.  On the mechanism of contraction and desensitization induced by substance P in the intestinal muscle of the guinea-pig.

Authors:  P Holzer; U Petsche
Journal:  J Physiol       Date:  1983-09       Impact factor: 5.182

5.  An enquiry into the mechanism by which substance P facilitates the phasic longitudinal contractions of the rabbit ileum.

Authors:  P Holzer
Journal:  J Physiol       Date:  1982-04       Impact factor: 5.182
  5 in total

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