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Literature DB >> 6165080

Interferon action: RNA cleavage pattern of a (2'-5')oligoadenylate--dependent endonuclease.

Abstract

One of the mediators of interferon action is a latent endoribonuclease (ribonuclease L) that is activated by (2'-5')oligoadenylates. Among the homopolymers of the four common ribonucleotides, activated ribonuclease L degrades at an appreciable rate only polyuridylic acid. In two natural RNA's tested the most frequent ribonuclease L cleavages occur after UA, UG, and UU (A, adenine; U, uracil; and G, guanine) and much less frequent cleavages after CA and AC (C, cytosine).

Entities: Chemical Gene

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Year: 1981 PMID： 6165080 DOI： 10.1126/science.6165080

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

101 in total

1. Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p.

Authors: B Dong; M Niwa; P Walter; R H Silverman
Journal: RNA Date: 2001-03 Impact factor: 4.942

2. The Ebola virus VP35 protein functions as a type I IFN antagonist.

Authors: C F Basler; X Wang; E Mühlberger; V Volchkov; J Paragas; H D Klenk; A García-Sastre; P Palese
Journal: Proc Natl Acad Sci U S A Date: 2000-10-24 Impact factor: 11.205

3. Interferon-beta suppresses herpes simplex virus type 1 replication in trigeminal ganglion cells through an RNase L-dependent pathway.

Authors: Daniel J J Carr; Khaldun Al-khatib; Cassandra M James; Robert Silverman
Journal: J Neuroimmunol Date: 2003-08 Impact factor: 3.478

Interferon action: RNA cleavage pattern of a (2'-5')oligoadenylate--dependent endonuclease.

1. Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p.

2. The Ebola virus VP35 protein functions as a type I IFN antagonist.

3. Interferon-beta suppresses herpes simplex virus type 1 replication in trigeminal ganglion cells through an RNase L-dependent pathway.

Review 4. New insights into the role of RNase L in innate immunity.

5. A mammalian 2-5A system functions as an antiviral pathway in transgenic plants.

6. Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.

7. Innate immune responses induced by CpG oligodeoxyribonucleotide stimulation of ovine blood mononuclear cells.

8. Chemical synthesis and biological characterization of phosphorothioate analogs of 2', 5'-3'-deoxyadenylate trimer.

9. Structural basis for recognition of 2',5'-linked oligoadenylates by human ribonuclease L.

10. New sequence-specific human ribonuclease: purification and properties.