Literature DB >> 6164876

Regulation of B lymphocyte activation by the Fc portion of immunoglobulin.

E L Morgan, W O Weigle.   

Abstract

Murine splenic B lymphocytes are induced to proliferate and undergo polyclonal activation in the presence of Fc fragments, AHGG, antigen-antibody complexes, and CH3 fragments derived from plasmin digestion of human Ig. The unifying feature of the polyclonal antibody response induced by these agents is that in all cases a portion of the constant region of the Ig molecule (ie, Fc region) is present. Fragments of Ig lacking the Fc piece, such as Fab and F(ab)2 were found not to be stimulatory. In addition, a model is proposed to account for the regulatory effects of antigen-antibody complexes on an ongoing humoral immune response.

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Year:  1980        PMID： 6164876     DOI： 10.1002/jss.400140208

Source DB:  PubMed          Journal:  J Supramol Struct        ISSN： 0091-7419


  3 in total

1.  Isolation and identification of a biologically active peptide derived from the CH3 domain of human IgG1.

Authors:  E L Morgan; T E Hugli; W O Weigle
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

2.  Synthetic Fc peptide-mediated regulation of the immune response. I. Characterization of the immunomodulating properties of a synthetic 23-amino acid peptide derived from the sequence of the CH3 domain of human IgG1.

Authors:  E L Morgan; J E Shields; C S Campbell; R L Barton; G A Koppel; W O Weigle
Journal:  J Exp Med       Date:  1983-03-01       Impact factor: 14.307

3.  Anaphylatoxin-mediated regulation of the immune response. I. C3a-mediated suppression of human and murine humoral immune responses.

Authors:  E L Morgan; W O Weigle; T E Hugli
Journal:  J Exp Med       Date:  1982-05-01       Impact factor: 14.307
  3 in total

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