Literature DB >> 6164755

5-OH-Tryptophane in migraine: clinical and neurophysiological considerations.

A Boiardi, P Crenna, B Merati, S Negri, E Tansini, G Bussone.   

Abstract

The clinical effects of the protracted treatment with 5-OH Tryptophane (5-HTP) of some patients with chronic migraine are compared with other patients with acetylsalicylic acid. The pain threshold was neurophysiologically determined in migraneous on patients whose response to 5-HTP therapy was specially good. The results with 5-HTP can be accounted for by an action of the substance on the serotonin turnover with activation of the serotoninergic antinociceptive system.

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Year:  1981        PMID： 6164755     DOI： 10.1007/BF00313460

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  11 in total

1.  Comparative study of perceived pain and nociceptive flexion reflex in man.

Authors:  Jean Clau de Willer
Journal:  Pain       Date:  1977-02       Impact factor: 6.961

Review 2.  Serotonin receptors in the brain.

Authors:  H J Haigler; G K Aghajanian
Journal:  Fed Proc       Date:  1977-07

3.  The ingestion of serotonin precursors (L-5-hydroxytryptophan and L-tryptophan) improves migraine headache.

Authors:  F Sicuteri
Journal:  Headache       Date:  1973-04       Impact factor: 5.887

4.  Peripheral serotonin antagonists: failure to antagonize serotonin in brain areas receiving a prominent serotonergic input.

Authors:  H J Haigler; G K Aghajanian
Journal:  J Neural Transm       Date:  1974       Impact factor: 3.575

5.  Effects of acetylsalicylic acid on serum protein binding and metabolism of tryptophan in man.

Authors:  H G Smith; C Lakatos
Journal:  J Pharm Pharmacol       Date:  1971-03       Impact factor: 3.765

6.  5-hydroxytryptamine supersensitivity as a new theory of headache and central pain: a clinical pharmacological approach with p-chlorophenylalanine.

Authors:  F Sicuteri; B Anselmi; P L Del Bianco
Journal:  Psychopharmacologia       Date:  1973

7.  Cerebrospinal fluid 5-hydroxyindoleacetic acid level in migrainous patients during spontaneous attacks, during headache-free periods and following treatment with L-tryptophan.

Authors:  M Poloni; G Nappi; A Arrigo; F Savoldi
Journal:  Experientia       Date:  1974-06-15

8.  p-Chlorophenylalanine: a specific depletor of brain serotonin.

Authors:  B K Koe; A Weissman
Journal:  J Pharmacol Exp Ther       Date:  1966-12       Impact factor: 4.030

9.  Morphine abstinence and serotonin supersensitivity in man: analogies with the mechanism of migraine?

Authors:  F Sicuteri; P L Del Bianco; B Anselmi
Journal:  Psychopharmacology (Berl)       Date:  1979-10       Impact factor: 4.530

10.  Surgery in the rat during electrical analgesia induced by focal brain stimulation.

Authors:  D V Reynolds
Journal:  Science       Date:  1969-04-25       Impact factor: 47.728
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  1 in total

1.  PK/PD modeling of 5-hydroxytryptophan (5-HTP) challenge test with cortisol measurement in serum and saliva.

Authors:  Zheng Guan; Gabriel Jacobs; Hans van Pelt; Joop M A Van Gerven; Jacobus Burggraaf; Wei Zhao
Journal:  Pharmacol Res Perspect       Date:  2020-04
  1 in total

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