Literature DB >> 6164390

Demonstration of nitrogen coordination in metal--bleomycin complexes by electron spin--echo envelope spectroscopy.

R M Burger, A D Adler, S B Horwitz, W B Mims, J Peisach.   

Abstract

We have studied the Cu(II), Co(II), and Fe(III) complexes of the antineoplastic drug bleomycin by using electron spin--echo envelope spectroscopy. For all three complexes, nitrogen coordination of the metal ions is demonstrated. For the Cu(II)-- and Co(II)--drug complexes, we have been able to identify imidazole as a metal ligand.

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Year:  1981        PMID: 6164390     DOI: 10.1021/bi00509a045

Source DB:  PubMed          Journal:  Biochemistry        ISSN: 0006-2960            Impact factor:   3.162


  5 in total

1.  Electron spin-lattice relaxation of the [Cu(1.5) ... Cu(1.5)] dinuclear copper center in nitrous oxide reductase.

Authors:  S Pfenninger; W E Antholine; M E Barr; J S Hyde; P M Kroneck; W G Zumft
Journal:  Biophys J       Date:  1995-12       Impact factor: 4.033

2.  Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents.

Authors:  Erika M Becker; David B Lovejoy; Judith M Greer; Ralph Watts; Des R Richardson
Journal:  Br J Pharmacol       Date:  2003-03       Impact factor: 8.739

3.  Cytotoxic iron chelators: characterization of the structure, solution chemistry and redox activity of ligands and iron complexes of the di-2-pyridyl ketone isonicotinoyl hydrazone (HPKIH) analogues.

Authors:  Paul V Bernhardt; Lorraine M Caldwell; Timothy B Chaston; Piao Chin; Des R Richardson
Journal:  J Biol Inorg Chem       Date:  2003-10-15       Impact factor: 3.358

Review 4.  Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. General considerations, the nitrosoureas and alkylating agents.

Authors:  A G Bosanquet
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333

5.  ESR of copper and iron complexes with antitumor and cytotoxic properties.

Authors:  W E Antholine; B Kalyanaraman; D H Petering
Journal:  Environ Health Perspect       Date:  1985-12       Impact factor: 9.031

  5 in total

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