Literature DB >> 6163455

Effects of Ca2+ ionophore A23187 and Ca2+ deficiency on pancreatic phospholipids and amylase release in vitro.

R V Farese, R E Larson, M A Sabir.   

Abstract

The Ca2+ ionophore A23187 elicits a transient increase in pancreatic amylase release in vitro, and this is accompanied by a transient decrease in phosphatidyl inositol concentration. Effects of ionophore A23187 and carbachol on amylase release and phosphatidylinisitol breakdown are dependent on medium Ca2+. These results suggest that major secretagogue-induced, pancreatic phospholipid changes follow, rather than precede, changes in Ca2+ in the pancreas.

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Year:  1980        PMID： 6163455     DOI： 10.1016/0304-4165(80)90205-6

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  4 in total

1.  Calcium in the regulation of gravitropism by light.

Authors:  D O Perdue; A K LaFavre; A C Leopold
Journal:  Plant Physiol       Date:  1988       Impact factor: 8.340

2.  Effects of carbachol and pancreozymin (cholecystokinin-octapeptide) on polyphosphoinositide metabolism in the rat pancreas in vitro.

Authors:  J L Orchard; J S Davis; R E Larson; R V Farese
Journal:  Biochem J       Date:  1984-01-01       Impact factor: 3.857

3.  Role of Ca2+ in secretagogue-stimulated breakdown of phosphatidylinositol in rat pancreatic islets.

Authors:  K V Axen; U K Schubart; A D Blake; N Fleischer
Journal:  J Clin Invest       Date:  1983-07       Impact factor: 14.808

4.  Phospholipid turnover in isolated rat pancreatic acini. Consideration of the relative roles of phospholipase A2 and phospholipase C.

Authors:  S P Halenda; R P Rubin
Journal:  Biochem J       Date:  1982-12-15       Impact factor: 3.857
  4 in total

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