Literature DB >> 616321

The activity of the D-T diaphorase in experimental hepatomas.

N A Schor, H P Morris.   

Abstract

The study of some NAD(P)H dehydrogenating enzymes in one slow- and one fast-growing transplantable hepatoma has shown that the activity of the soluble enzyme D-T diaphorase is increased several-fold when compared with the activity of the control livers. The increase in enzyme activity is similar in both hepatomas, regardless of the rate of growth of the tumors. The activity of the glycerolphosphate, malic and lactic dehydrogenases are decreased in both tumors. The possible functional significance of these changes is discussed in the text.

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Year:  1977        PMID： 616321

Source DB:  PubMed          Journal:  Cancer Biochem Biophys        ISSN： 0305-7232


  8 in total

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Authors:  R Wallin; F Rossi; R Loeser; L L Key
Journal:  Biochem J       Date:  1990-07-15       Impact factor: 3.857

Review 2.  NAD(P)H:quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues.

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Journal:  Cancer Metastasis Rev       Date:  1993-06       Impact factor: 9.264

3.  Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity.

Authors:  A M Benson; M J Hunkeler; P Talalay
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

Review 4.  NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones.

Authors:  David Siegel; Chao Yan; David Ross
Journal:  Biochem Pharmacol       Date:  2011-12-24       Impact factor: 6.100

Review 5.  Enhancing Oral Absorption of β-Lapachone: Progress Till Date.

Authors:  Marival Bermejo; Victor Mangas-Sanjuan; Isabel Gonzalez-Alvarez; Marta Gonzalez-Alvarez
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2017-02       Impact factor: 2.569

6.  NAD(P)H nitroblue tetrazolium reductase levels in apparently normoxic tissues: a histochemical study correlating enzyme activity with binding of radiolabelled misonidazole.

Authors:  L M Cobb; T Hacker; J Nolan
Journal:  Br J Cancer       Date:  1990-04       Impact factor: 7.640

7.  β-Lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells.

Authors:  E J Park; K-J Min; T-J Lee; Y H Yoo; Y-S Kim; T K Kwon
Journal:  Cell Death Dis       Date:  2014-05-15       Impact factor: 9.685

Review 8.  Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues.

Authors:  Danielly C Ferraz da Costa; Luciana Pereira Rangel; Mafalda Maria Duarte da Cunha Martins-Dinis; Giulia Diniz da Silva Ferretti; Vitor F Ferreira; Jerson L Silva
Journal:  Molecules       Date:  2020-02-18       Impact factor: 4.927
  8 in total

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