Literature DB >> 6162200

F-cell production in sickle cell anemia: regulation by genes linked to beta-hemoglobin locus.

G J Dover, S H Boyer, M E Pembrey.   

Abstract

Strong correlation of F-reticulocyte levels within sib pairs with sickle cell (SS) anemia suggests that the wide-ranging levels found in the SS population are governed by genes linked to the beta S-site. Correlations between F-cell levels in parents and F-reticulocyte levels in their children indicates that these same genes regulate F-cell production in nonanemic persons. Comparison of outcrossed and inbred SS populations suggests that relative well-being arises from homozygosity for alleles dictating high F-reticulocyte response to anemia.

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Year:  1981        PMID： 6162200     DOI： 10.1126/science.6162200

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  17 in total

Review 1.  Genetic modifiers of sickle cell disease.

Authors:  Martin H Steinberg; Paola Sebastiani
Journal:  Am J Hematol       Date:  2012-05-28       Impact factor: 10.047

Review 2.  Fetal hemoglobin in sickle cell anemia.

Authors:  Idowu Akinsheye; Abdulrahman Alsultan; Nadia Solovieff; Duyen Ngo; Clinton T Baldwin; Paola Sebastiani; David H K Chui; Martin H Steinberg
Journal:  Blood       Date:  2011-04-13       Impact factor: 22.113

Review 3.  Hb F in sickle cell anemia.

Authors:  A D Adekile; T H Huisman
Journal:  Experientia       Date:  1993-01-15

4.  Alpha thalassemia changes erythrocyte heterogeneity in sickle cell disease.

Authors:  C T Noguchi; G J Dover; G P Rodgers; G R Serjeant; S E Antonarakis; N P Anagnou; D R Higgs; D J Weatherall; A N Schechter
Journal:  J Clin Invest       Date:  1985-05       Impact factor: 14.808

5.  The natural history of homozygous S sickle cell anemia in two sisters.

Authors:  T L Yarboro
Journal:  J Natl Med Assoc       Date:  1995-05       Impact factor: 1.798

6.  Heterocellular hereditary persistence of fetal hemoglobin (HPFH). Molecular mechanisms of abnormal gamma-gene expression in association with beta thalassemia and linkage relationship with the beta-globin gene cluster.

Authors:  A Giampaolo; F Mavilio; N M Sposi; A Carè; A Massa; L Cianetti; M Petrini; R Russo; M D Cappellini; M Marinucci
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

7.  Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex.

Authors:  S Charache; G Dover; K Smith; C C Talbot; M Moyer; S Boyer
Journal:  Proc Natl Acad Sci U S A       Date:  1983-08       Impact factor: 11.205

Review 8.  Developmental genetics of the human haemoglobins.

Authors:  W G Wood; D J Weatherall
Journal:  Biochem J       Date:  1983-10-01       Impact factor: 3.857

9.  Heterogeneity of sickle-cell anemia based on a profile of hematological variables.

Authors:  D J Odenheimer; C F Whitten; D L Rucknagel; S A Sarnaik; C F Sing
Journal:  Am J Hum Genet       Date:  1983-11       Impact factor: 11.025

10.  Fetal hemoglobin accumulation in vitro. Effect of adherent mononuclear cells.

Authors:  J Javid; P K Pettis
Journal:  J Clin Invest       Date:  1983-05       Impact factor: 14.808
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