Literature DB >> 6162014

The 9L rat brain tumor: description and application of an animal model.

M Weizsaecker, D F Deen, M L Rosenblum, T Hoshino, P H Gutin, M Barker.   

Abstract

Animal models allow determination of tumor response to anticancer agents under various experimental conditions. The chemically induced 9L rat brian tumor has been developed as both in vivo and in vitro models. Animal survival, clonogenic cell survival, and tumor growth delay provide means to measure the effectiveness of treatment modalities in this tumor model. Monolayer cultures, multicellular spheroid cultures, brain tumors, and flank tumors have been used to study the influence of different biological entities of the 9L model on the response to treatment with radiation and/or BCNU (1,3-bis (2-chloroethyl)-1-nitrosourea).

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Year:  1981        PMID： 6162014     DOI： 10.1007/BF00313280

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  19 in total

1.  Experimental evaluation of potential anticancer agents. VI. Anatomical distribution of leukemic cells and failure of chemotherapy.

Authors:  H E SKIPPER; F M SCHABEL; M W TRADER; J R THOMSON
Journal:  Cancer Res       Date:  1961-10       Impact factor: 12.701

2.  Experimental evaluation of potential anticancer agents VIII. Effects of certain nitrosoureas on intracerebral L1210 leukemia.

Authors:  F M SCHABEL; T P JOHNSTON; G S McCALEB; J A MONTGOMERY; W R LASTER; H E SKIPPER
Journal:  Cancer Res       Date:  1963-06       Impact factor: 12.701

3.  Comparison of in vitro methods to determine drug-induced cell lethality.

Authors:  P R Roper; B Drewinko
Journal:  Cancer Res       Date:  1976-07       Impact factor: 12.701

4.  BCNU and X-ray therapy of intracerebral 9L rat tumors.

Authors:  M Barker; D F Deen; D G Baker
Journal:  Int J Radiat Oncol Biol Phys       Date:  1979-09       Impact factor: 7.038

5.  BCNU-modification of the in vitro radiation response in 9L brain tumor cells of rats.

Authors:  K T Wheeler; D F Deen; C B Wilson; M E Williams; S Sheppard
Journal:  Int J Radiat Oncol Biol Phys       Date:  1977 Jan-Feb       Impact factor: 7.038

6.  Development of a 9L rat brain tumor cell multicellular spheroid system and its response to 1,3-bis(2-chloroethyl)-1-nitrosourea and radiation.

Authors:  D F Deen; T Hoshino; M E Williams; I Muraoka; K D Knebel; M Barker
Journal:  J Natl Cancer Inst       Date:  1980-06       Impact factor: 13.506

7.  Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity.

Authors:  G G Steel; M J Peckham
Journal:  Int J Radiat Oncol Biol Phys       Date:  1979-01       Impact factor: 7.038

8.  In vivo clonogenic tumor cell kinetics following 1,3-bis(2-chloroethyl)-1-nitrosourea brain tumor therapy.

Authors:  M L Rosenblum; K D Knebel; D A Vasquez; C B Wilson
Journal:  Cancer Res       Date:  1976-10       Impact factor: 12.701

9.  Development of an in vitro colony formation assay for the evaluation of in vivo chemotherapy of a rat brain tumor.

Authors:  M L Rosenblum; K D Knebel; K T Wheeler; M Barker; C B Wilson
Journal:  In Vitro       Date:  1975 Sep-Oct

10.  Is cell survival a determinant of the in situ response of 9L tumours?

Authors:  K T Wheeler; C A Wallen
Journal:  Br J Cancer Suppl       Date:  1980-04
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  28 in total

1.  Single-step conversion of cells to retrovirus vector producers with herpes simplex virus-Epstein-Barr virus hybrid amplicons.

Authors:  M Sena-Esteves; Y Saeki; S M Camp; E A Chiocca; X O Breakefield
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

2.  Functional coexpression of HSV-1 thymidine kinase and green fluorescent protein: implications for noninvasive imaging of transgene expression.

Authors:  A Jacobs; M Dubrovin; J Hewett; M Sena-Esteves; C W Tan; M Slack; M Sadelain; X O Breakefield; J G Tjuvajev
Journal:  Neoplasia       Date:  1999-06       Impact factor: 5.715

3.  Liposome-mediated therapy of intracranial brain tumors in a rat model.

Authors:  U S Sharma; A Sharma; R I Chau; R M Straubinger
Journal:  Pharm Res       Date:  1997-08       Impact factor: 4.200

4.  The VM model of glioma: preparation of multicellular tumour spheroids (MTS) and their response to chemotherapy.

Authors:  R Bradford; J L Darling; N Sier; D G Thomas
Journal:  J Neurooncol       Date:  1990-10       Impact factor: 4.130

5.  In vivo characterization of several rodent glioma models by 1H MRS.

Authors:  Sabrina Doblas; Ting He; Debra Saunders; Jessica Hoyle; Nataliya Smith; Quentin Pye; Megan Lerner; Randy L Jensen; Rheal A Towner
Journal:  NMR Biomed       Date:  2011-09-23       Impact factor: 4.044

6.  Contributions of cell kill and posttreatment tumor growth rates to the repopulation of intracerebral 9L tumors after chemotherapy: an MRI study.

Authors:  B D Ross; Y J Zhao; E R Neal; L D Stegman; M Ercolani; O Ben-Yoseph; T L Chenevert
Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-09       Impact factor: 11.205

7.  A model for experimental interstitial radiotherapy using intracerebral D-54MG glioma xenografts in athymic mice.

Authors:  B E Lippitz
Journal:  Neurosurg Rev       Date:  1995       Impact factor: 3.042

8.  Photoradiation therapy of 9L-gliosarcoma in rats: hematoporphyrin derivative (types I and II) followed by laser energy.

Authors:  M K Cheng; J McKean; B Mielke; J Tulip; D Boisvert
Journal:  J Neurooncol       Date:  1985       Impact factor: 4.130

9.  Xenograft transplantation of human malignant astrocytoma cells into immunodeficient rats: an experimental model of glioblastoma.

Authors:  Flávio Key Miura; Maria Jose Ferreira Alves; Mussya Cisotto Rocha; Roseli da Silva; Sueli Mieko Oba-Shinjo; Suely Kazue Nagahashi Marie
Journal:  Clinics (Sao Paulo)       Date:  2010-03       Impact factor: 2.365

10.  Mechanism of dexamethasone suppression of brain tumor-associated vascular permeability in rats. Involvement of the glucocorticoid receptor and vascular permeability factor.

Authors:  J D Heiss; E Papavassiliou; M J Merrill; L Nieman; J J Knightly; S Walbridge; N A Edwards; E H Oldfield
Journal:  J Clin Invest       Date:  1996-09-15       Impact factor: 14.808
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