Literature DB >> 6160600

A review of clinical studies of pepleomycin.

S Oka.   

Abstract

Pulmonary toxicity was less frequent in pepleomycin treatment of squamous cell carcinoma than in bleomycin treatment. The tumor-regressing effect appeared at about day 10 of pepleomycin treatment, and at about day 21 of bleomycin treatment. The cumulative dose of pepleomycin to complete remission was smaller than that of bleomycin. Pepleomycin is effective against bleomycin-sensitive malignancies: squamous cell carcinoma and Hodgkin's disease. It is more effective than bleomycin against lymph node metastases. Pepleomycin may have a broader antitumor spectrum: prostatic carcinoma responded.

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Year:  1980        PMID： 6160600     DOI： 10.1007/978-3-642-81488-4_21

Source DB:  PubMed          Journal:  Recent Results Cancer Res        ISSN： 0080-0015


  5 in total

1.  Structural changes of Zn(II)bleomycin complexes when bound to DNA hairpins containing the 5'-GT-3' and 5'-GC-3' binding sites studied through NMR spectroscopy.

Authors:  Shelby E Follett; Sally A Murray; Azure D Ingersoll; Teresa M Reilly; Teresa E Lehmann
Journal:  Magnetochemistry       Date:  2017-12-27

2.  NMR study of the effects of some bleomycin C-termini on the structure of a DNA hairpin with the 5'-GC-3' binding site.

Authors:  Teresa E Lehmann; Sally A Murray; Azure D Ingersoll; Teresa M Reilly; Shelby E Follett; Kevin E Macartney; Mark H Harpster
Journal:  J Biol Inorg Chem       Date:  2016-11-17       Impact factor: 3.358

3.  Interaction of Zn(II)bleomycin-A2 and Zn(II)peplomycin with a DNA hairpin containing the 5'-GT-3' binding site in comparison with the 5'-GC-3' binding site studied by NMR spectroscopy.

Authors:  Shelby E Follett; Azure D Ingersoll; Sally A Murray; Teresa M Reilly; Teresa E Lehmann
Journal:  J Biol Inorg Chem       Date:  2017-07-26       Impact factor: 3.358

4.  Functional characterization of tlmK unveiling unstable carbinolamide intermediates in the tallysomycin biosynthetic pathway.

Authors:  Liyan Wang; Meifeng Tao; Evelyn Wendt-Pienkoski; Ute Galm; Jane M Coughlin; Ben Shen
Journal:  J Biol Chem       Date:  2009-02-03       Impact factor: 5.157

Review 5.  Contributions of NMR to the understanding of the coordination chemistry and DNA interactions of metallo-bleomycins.

Authors:  Teresa Lehmann; Elena Topchiy
Journal:  Molecules       Date:  2013-08-02       Impact factor: 4.411
  5 in total

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