Literature DB >> 6160589

Human leukocyte interferon: structural and biological relatedness to adrenocorticotropic hormone and endorphins.

J E Blalock, E M Smith.   

Abstract

Anti-alpha-corticotropin [anti-ACTH alpha (1-13)](also alpha-melanotropin) and anti-gamma-endorphin antisera neutralized human leukocyte interferon activity but not fibroblast interferon activity. Human leukocyte interferon was not neutralized by anti-human lutenizing hormone (lutropin) or follicle-stimulating hormone (follitropin) antisra. Conversely, antisera to human leukocyte interferon neutralized ACTH activity. The neturalization of human leukocyte interferon by anti-human leukocyte interferon serum was partially blocked by ACTH. These studies show strong antigenic relatedness among human leukocyte interferon, ACTH, and endorphins, implying that there are underlying structural similarities. Structural relatedness is shown by pepsin cleavage of ACTH activity from human leukocyte interferon. The implication for the natural functions of human leukocyte interferon are discussed.

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Year:  1980        PMID： 6160589      PMCID： PMC350194          DOI： 10.1073/pnas.77.10.5972

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

1.  Hormone-producing cultures of adrenal and pituitary tumor origin.

Authors:  V BUONASSISI; G SATO; A I COHEN
Journal:  Proc Natl Acad Sci U S A       Date:  1962-07-15       Impact factor: 11.205

2.  Virus interference. I. The interferon.

Authors:  A ISAACS; J LINDENMANN
Journal:  Proc R Soc Lond B Biol Sci       Date:  1957-09-12

3.  Nonsensitized lymphocytes produce leukocyte interferon when cultured with foreign cells.

Authors:  J E Blalock; M P Langford; J Georgiades; G J Stanton
Journal:  Cell Immunol       Date:  1979-03-01       Impact factor: 4.868

Review 4.  Antitumor effects of interferon.

Authors:  I Gresser; M G Tovey
Journal:  Biochim Biophys Acta       Date:  1978-10-27

5.  Purified human immune interferon has more potent anticellular activity than fibroblast or leukocyte interferon.

Authors:  J E Blalock; J A Georgiades; M P Langford; H M Johnson
Journal:  Cell Immunol       Date:  1980-02       Impact factor: 4.868

6.  Amino terminal sequence of the major component of human lymphoblastoid interferon.

Authors:  K C Zoon; M E Smith; P J Bridgen; C B Anfinsen; M W Hunkapiller; L E Hood
Journal:  Science       Date:  1980-02-01       Impact factor: 47.728

7.  Common precursor to corticotropins and endorphins.

Authors:  R E Mains; B A Eipper; N Ling
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

8.  Common pathways of interferon and hormonal action.

Authors:  J E Blalock; J D Stanton
Journal:  Nature       Date:  1980-01-24       Impact factor: 49.962

9.  Human fibroblast interferon: amino acid analysis and amino terminal amino acid sequence.

Authors:  E Knight; M W Hunkapiller; B D Korant; R W Hardy; L E Hood
Journal:  Science       Date:  1980-02-01       Impact factor: 47.728

10.  Stimulation of steroidogenesis in tissue culture by enterotoxigenic Escherichia coli and its neutralization by specific antiserum.

Authors:  S T Donta; D M Smith
Journal:  Infect Immun       Date:  1974-03       Impact factor: 3.441
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  30 in total

1.  Immunoreactive growth hormone production by human lymphocyte cell lines.

Authors:  T L Kao; S C Supowit; E A Thompson; W J Meyer
Journal:  Cell Mol Neurobiol       Date:  1992-10       Impact factor: 5.046

Review 2.  Immunologic and neuroendocrine interactions in pregnancy.

Authors:  R Rani; K K Mittal
Journal:  Indian J Pediatr       Date:  1989 Mar-Apr       Impact factor: 1.967

3.  Neuropeptides as signal molecules in common with leukocytes and the hypothalamic-pituitary-adrenal axis.

Authors:  Eric M Smith
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Authors:  János Kálmán; András Palotás; Anna Juhász; Agnes Rimanóczy; Marietta Hugyecz; Zsuzsa Kovács; Gabriella Galsi; Zoltán Szabó; Magdolna Pákáski; Liliána Z Fehér; Zoltán Janka; László G Puskás
Journal:  Neurochem Res       Date:  2005-11       Impact factor: 3.996

5.  The possibility of the use of interferon in the treatment of alcoholism.

Authors:  N A Aliev; M A Mustafaev
Journal:  Neurosci Behav Physiol       Date:  1993 Jul-Aug

6.  Effect of interferon-alpha on DOI-induced wet-dog shakes in rats.

Authors:  A Kugaya; A Kagaya; Y Uchitomi; N Yokota; S Yamawaki
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

Review 7.  Immunological and functional aspects of H-Y antigen.

Authors:  U Müller
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

Review 8.  Neural and Pavlovian influences on immunity.

Authors:  R W Brittain; N I Wiener
Journal:  Pavlov J Biol Sci       Date:  1985 Oct-Dec

9.  Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents alcohol drinking but not seeking behaviour in adulthood.

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Journal:  Neuropharmacology       Date:  2017-09-22       Impact factor: 5.250

10.  Involvement of central opioid systems in human interferon-alpha induced immobility in the mouse forced swimming test.

Authors:  M Makino; Y Kitano; C Komiyama; M Hirohashi; K Takasuna
Journal:  Br J Pharmacol       Date:  2000-07       Impact factor: 8.739
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