Literature DB >> 6160347

Adrenaline-induced hypertension in rats.

H Majewski, L H Tung, M J Rand.   

Abstract

Rats were given a slow-release depot implantation containing adrenaline (0.33 mumole/kg). Adrenaline was released from the implant, giving a plasma level of 1.0 nmole/liter the day after implantation. Adrenaline-treated rats had elevated blood pressures compared to control rats from 1 day to 8 weeks after treatment. However, 8 weeks after treatment no adrenaline from the implant was found in the plasma, suggesting that at this time factors other than the adrenaline were responsible for maintaining the rise in blood pressure. In rats given metoprolol tartrate (5 mg/kg/day, p.o.), adrenaline treatment did not increase the blood pressure.

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Year:  1981        PMID： 6160347     DOI： 10.1097/00005344-198101000-00016

Source DB:  PubMed          Journal:  J Cardiovasc Pharmacol        ISSN： 0160-2446            Impact factor:   3.105


  15 in total

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Authors:  F Péronnet; D Massicotte; J E Paquet; G Brisson; J de Champlain
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2.  The effect of adrenal demedullation on cardiovascular responses to environmental stimulation in conscious rats.

Authors:  K R Borkowski; E Kelly
Journal:  Br J Pharmacol       Date:  1986-08       Impact factor: 8.739

3.  How intrinsic sympathomimetic activity modulates the haemodynamic responses to beta-adrenoceptor antagonists. A clue to the nature of their antihypertensive mechanism.

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4.  Elevated plasma noradrenaline in response to beta-adrenoceptor stimulation in man.

Authors:  H H Vincent; A J Man In't Veld; F Boomsma; G J Wenting; M A Schalekamp
Journal:  Br J Clin Pharmacol       Date:  1982-05       Impact factor: 4.335

5.  Proceedings of the British Pharmacological Society. Abstracts.

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Journal:  Br J Pharmacol       Date:  1984-03       Impact factor: 8.739

6.  Proceedings of the British Pharmacological Society. 11th-13th April, 1984. Abstracts.

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Journal:  Br J Pharmacol       Date:  1984-06       Impact factor: 8.739

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8.  Activation of prejunctional beta-adrenoceptors in rat atria by adrenaline applied exogenously or released as a co-transmitter.

Authors:  H Majewski; M J Rand; L H Tung
Journal:  Br J Pharmacol       Date:  1981-07       Impact factor: 8.739

9.  The effect of bilateral adrenal demedullation on vascular reactivity and blood pressure in spontaneously hypertensive rats.

Authors:  K R Borkowski; P Quinn
Journal:  Br J Pharmacol       Date:  1983-11       Impact factor: 8.739

10.  Postnatal development of vascular beta-adrenoceptor-mediated responses and the increase in the adrenaline content of the adrenal gland have a parallel time course.

Authors:  M Q Paiva; D Moura; M J Vaz-da-Silva; S Guimarães
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-07       Impact factor: 3.000
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