Literature DB >> 6160139

Tetrocarcins, novel antitumor antibiotics. II. Isolation, characterization and antitumor activity.

T Tamaoki, M Kasai, K Shirahata, S Ohkubo, M Morimoto, K Mineura, S Ishii, F Tomita.   

Abstract

Novel antitumor antibiotics, tetrocarcin complex composed of three components (A, B and C) were isolated from the culture broth of Micromonospora chalcea KY11091 through various procedures. Tetrocarcins showed marked activity against experimental tumors such as mouse sarcoma 180 and mouse leukemia P388. Multiple injections showed better therapeutic effect against tumors. Mode of action of tetrocarcin A against Bacillus subtilis was found to be through the inhibition of RNA synthesis.

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Year:  1980        PMID： 6160139     DOI： 10.7164/antibiotics.33.946

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  9 in total

Review 1.  Natural [4 + 2]-Cyclases.

Authors:  Byung-Sun Jeon; Shao-An Wang; Mark W Ruszczycky; Hung-Wen Liu
Journal:  Chem Rev       Date:  2016-12-01       Impact factor: 60.622

Review 2.  Modulating splicing with small molecular inhibitors of the spliceosome.

Authors:  Kerstin A Effenberger; Veronica K Urabe; Melissa S Jurica
Journal:  Wiley Interdiscip Rev RNA       Date:  2016-07-21       Impact factor: 9.957

3.  Synthetic Strategies Toward the Decalin Motif of Maklamicin and Related Spirotetronates.

Authors:  Michelle H Lacoske; Jing Xu; Noel Mansour; Chao Gao; Emmanuel A Theodorakis
Journal:  Org Chem Front       Date:  2015-04-01       Impact factor: 5.281

4.  Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.

Authors:  Jie Fang; Yiping Zhang; Lijuan Huang; Xinying Jia; Qi Zhang; Xu Zhang; Gongli Tang; Wen Liu
Journal:  J Bacteriol       Date:  2008-06-27       Impact factor: 3.490

Review 5.  The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars.

Authors:  Chia-I Lin; Reid M McCarty; Hung-wen Liu
Journal:  Chem Soc Rev       Date:  2013-01-25       Impact factor: 54.564

6.  Structure and activity of lobophorins from a turrid mollusk-associated Streptomyces sp.

Authors:  Zhenjian Lin; Michael Koch; Christopher D Pond; Gaiselle Mabeza; Romell A Seronay; Gisela P Concepcion; Louis R Barrows; Baldomero M Olivera; Eric W Schmidt
Journal:  J Antibiot (Tokyo)       Date:  2013-11-13       Impact factor: 2.649

Review 7.  Spirotetronate polyketides as leads in drug discovery.

Authors:  Michelle H Lacoske; Emmanuel A Theodorakis
Journal:  J Nat Prod       Date:  2014-12-01       Impact factor: 4.050

8.  Tetrocarcin Q, a New Spirotetronate with a Unique Glycosyl Group from a Marine-Derived Actinomycete Micromonospora carbonacea LS276.

Authors:  Ting Gong; Xin Zhen; Xing-Lun Li; Jing-Jing Chen; Tian-Jiao Chen; Jin-Ling Yang; Ping Zhu
Journal:  Mar Drugs       Date:  2018-02-24       Impact factor: 5.118

9.  Wychimicins, a new class of spirotetronate polyketides from Actinocrispum wychmicini MI503-A4.

Authors:  Tomoyuki Kimura; Maya Umekita; Masaki Hatano; Chigusa Hayashi; Ryuichi Sawa; Masayuki Igarashi
Journal:  J Antibiot (Tokyo)       Date:  2022-09-07       Impact factor: 3.424
  9 in total

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