Literature DB >> 6159828

Dextran sulphate induced arthritis in rabbits.

J Steinberg, C B Sledge, J Noble, H G Gillies.   

Abstract

Persistent effects of a short course of intra-articular dextran sulphate, dextrans, or chondroitin sulphate were examined in rabbit knees. Only dextran sulphate produced gross arthritis, associated with high synovial acid phosphatase and beta-glucuronidase activities. Synovial degradative capacity in synovium-cartilage cocultures was increased 2-fold by dextran sulphate and 1.5-fold by chondroitin sulphate treatments. Stimulation of cartilage breakdown in vitro paralleled the content of synovial marker enzyme at death of the animal, but the 2 responses could be dissociated.

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Year:  1980        PMID： 6159828      PMCID： PMC1000562          DOI： 10.1136/ard.39.4.387

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  17 in total

1.  Carrageenin-induced arthritis. I. The effect of intraarticular carrageenin on the chemical composition of articular cartilage.

Authors:  D A Lowther; G C Gillard
Journal:  Arthritis Rheum       Date:  1976 Jul-Aug

Review 2.  Lysosomal mechanisms of tissue injury in arthritis.

Authors:  G Weissmann
Journal:  N Engl J Med       Date:  1972-01-20       Impact factor: 91.245

3.  Environmental control of macromolecular synthesis in cartilage and bone: morphogenetic response to hyaluronidase.

Authors:  S F Jackson
Journal:  Proc R Soc Lond B Biol Sci       Date:  1970-09-29

4.  Cellular control of macromolecular synthesis: rates of synthesis of extracellular macromolecules during and after depletion by papain.

Authors:  H B Bosmann
Journal:  Proc R Soc Lond B Biol Sci       Date:  1968-03-26

5.  Biochemical and metabolic abnormalities in osteoarthritic human cartilage.

Authors:  H J Mankin
Journal:  Fed Proc       Date:  1973-04

6.  Heparin, dextran and dextran sulfate: effect on lysosomes from embryonic cartilage.

Authors:  C B Sledge; W W Blackburn
Journal:  Calcif Tissue Res       Date:  1968

7.  Light and electron microscope studies in carragheenin, adjuvant, and tuberculin-induced arthris.

Authors:  K D Muirden; G Peace
Journal:  Ann Rheum Dis       Date:  1969-07       Impact factor: 19.103

8.  The quantitative measurement of Alcian Blue-glycosaminoglycan complexes.

Authors:  P Whiteman
Journal:  Biochem J       Date:  1973-02       Impact factor: 3.857

9.  Replacement of proteoglycans in embryonic chick cartilage in organ culture after treatment with testicular hyaluronidase.

Authors:  T E Hardingham; S Fitton-Jackson; H Muir
Journal:  Biochem J       Date:  1972-08       Impact factor: 3.857

10.  Properties of fractionated chondroitin sulphate from ox nasal septa.

Authors:  A Wasteson
Journal:  Biochem J       Date:  1971-05       Impact factor: 3.857
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  1 in total

Review 1.  Animal models for osteoarthritis: processes, problems and prospects.

Authors:  K P Pritzker
Journal:  Ann Rheum Dis       Date:  1994-06       Impact factor: 19.103
  1 in total

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