Literature DB >> 6159577

DNA-RNA hybrid duplexes containing oligo(dA:rU) sequences are exceptionally unstable and may facilitate termination of transcription.

F H Martin, I Tinoco.   

Abstract

A DNA-RNA hybrid oligonucleotide duplex, dC(pA) 5pG:rC(pU)5pG, which contains a (dA:rU) 5 sequence, is at least 200 times less stable at room temperature than the corresponding duplex containing an (rA:dT) 5 sequence, rC(pA)5pG:dC(pT)5pG. This result provides an explanation for the finding that most primary RNA transcripts terminate in several consecutive rU residues, but not rA residues. It strongly supports the idea that instability of the DNA-RNA hybrid at the growing point of transcription plays a role in termination of transcription.

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Year:  1980        PMID： 6159577      PMCID： PMC324078          DOI： 10.1093/nar/8.10.2295

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  13 in total

1.  3'-Terminal nucleotide sequences in the genome RNA of picornaviruses.

Authors:  A G Porter; P Fellner; D N Black; D J Rowlands; T J Harris; F Brown
Journal:  Nature       Date:  1978-11-16       Impact factor: 49.962

Review 2.  Control of transcription termination.

Authors:  S Adhya; M Gottesman
Journal:  Annu Rev Biochem       Date:  1978       Impact factor: 23.643

3.  Letter: The structure of polydeoxyguanylic acid with polydeoxycytidylic acid.

Authors:  S Arnott; E Selsing
Journal:  J Mol Biol       Date:  1974-09-15       Impact factor: 5.469

4.  Molecular conformations and structure transitions of RNA complementary helices and their possible biological significance.

Authors:  S Arnott; W Fuller; A Hodgson; I Prutton
Journal:  Nature       Date:  1968-11-09       Impact factor: 49.962

5.  Self-complementary oligoribonucleotides: adenylic acid-uridylic acid block copolymers.

Authors:  F H Martin; O C Uhlenbeck; P Doty
Journal:  J Mol Biol       Date:  1971-04-28       Impact factor: 5.469

6.  Rous sarcoma virus genome is terminally redundant: the 5' sequence.

Authors:  W A Haseltine; A M Maxam; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1977-03       Impact factor: 11.205

7.  Sequences and efficiencies of proposed mRNA terminators.

Authors:  J E McMahon; I Tinoco
Journal:  Nature       Date:  1978-01-19       Impact factor: 49.962

8.  Structures for the polynucleotide complexes poly(dA) with poly (dT) and poly(dT) with poly(dA) with poly (dT).

Authors:  S Arnott; E Selsing
Journal:  J Mol Biol       Date:  1974-09-15       Impact factor: 5.469

9.  R loop mapping of the 18S and 28S sequences in the long and short repeating units of Drosophila melanogaster rDNA.

Authors:  R L White; D S Hogness
Journal:  Cell       Date:  1977-02       Impact factor: 41.582

10.  Physical and chemical characterization of two- and three-stranded adenine-thymine and adenine-uracil homopolymer complexes.

Authors:  M Riley; B Maling
Journal:  J Mol Biol       Date:  1966-09       Impact factor: 5.469
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  107 in total

1.  Conserved economics of transcription termination in eubacteria.

Authors:  Shyam Unniraman; Ranjana Prakash; Valakunja Nagaraja
Journal:  Nucleic Acids Res       Date:  2002-02-01       Impact factor: 16.971

2.  Prediction of rho-independent transcriptional terminators in Escherichia coli.

Authors:  E A Lesnik; R Sampath; H B Levene; T J Henderson; J A McNeil; D J Ecker
Journal:  Nucleic Acids Res       Date:  2001-09-01       Impact factor: 16.971

3.  Factors affecting start site selection at the Escherichia coli fis promoter.

Authors:  Kimberly A Walker; Robert Osuna
Journal:  J Bacteriol       Date:  2002-09       Impact factor: 3.490

4.  A high density of cis-information terminates RNA Polymerase III on a 2-rail track.

Authors:  Aneeshkumar G Arimbasseri; Richard J Maraia
Journal:  RNA Biol       Date:  2015-12-04       Impact factor: 4.652

5.  Effects of DNA base analogs on transcription termination at the tryptophan operon attenuator of EScherichia coli.

Authors:  P J Farnham; T Platt
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205

Review 6.  Transcription termination by the eukaryotic RNA polymerase III.

Authors:  Aneeshkumar G Arimbasseri; Keshab Rijal; Richard J Maraia
Journal:  Biochim Biophys Acta       Date:  2012-10-23

7.  Effects of site-specific substitution of 5-fluorouridine on the stabilities of duplex DNA and RNA.

Authors:  P V Sahasrabudhe; R T Pon; W H Gmeiner
Journal:  Nucleic Acids Res       Date:  1995-10-11       Impact factor: 16.971

8.  Structural basis for the RNA binding selectivity of oligonucleotide analogues containing alkylsulfide internucleoside linkages and 2'-substituted 3'-deoxyribonucleosides.

Authors:  M J Damha; B Meng; D Wang; C G Yannopoulos; G Just
Journal:  Nucleic Acids Res       Date:  1995-10-11       Impact factor: 16.971

9.  Synthesis and hybridization studies on two complementary nona(2'-O-methyl)ribonucleotides.

Authors:  H Inoue; Y Hayase; A Imura; S Iwai; K Miura; E Ohtsuka
Journal:  Nucleic Acids Res       Date:  1987-08-11       Impact factor: 16.971

10.  Translation of 2'-modified mRNA in vitro and in vivo.

Authors:  H Aurup; A Siebert; F Benseler; D Williams; F Eckstein
Journal:  Nucleic Acids Res       Date:  1994-11-25       Impact factor: 16.971
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