Literature DB >> 6159463

Teratogenic effect of an inhibitor of cholesterol synthesis (AY 9944) in rats: correlation with maternal cholesterolemia.

C Roux, R Dupuis, C Horvath, J N Talbot.   

Abstract

The teratogenic action of AY 9944, an inhibitor of cholesterol synthesis, was previously shown. Its prevention by simultaneous administration of cholesterol led to the hypothesis that this action is correlated with the decrease in cholesterol. The present investigation demonstrates that there is an inverse correlation between holoprosencephalic type of malformations and maternal cholesterolemia and that, in Wistar rats, 0.30 g/liter of cholesterolemia is a threshold under which these malformations can be observed.

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Year:  1980        PMID： 6159463     DOI： 10.1093/jn/110.11.2310

Source DB:  PubMed          Journal:  J Nutr        ISSN： 0022-3166            Impact factor:   4.798


  13 in total

Review 1.  Malformation syndromes caused by disorders of cholesterol synthesis.

Authors:  Forbes D Porter; Gail E Herman
Journal:  J Lipid Res       Date:  2010-10-07       Impact factor: 5.922

2.  Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome.

Authors:  Libin Xu; Wei Liu; Lowell G Sheflin; Steven J Fliesler; Ned A Porter
Journal:  J Lipid Res       Date:  2011-08-04       Impact factor: 5.922

3.  Statins repress hedgehog signaling in medulloblastoma with no bone toxicities.

Authors:  Qianhai Fan; Tingting Gong; Chaonan Zheng; Jessica M Y Ng; Jianquan Chen; Cynthia Myers; Harvey Hensley; Tom Curran; Zeng-Jie Yang
Journal:  Oncogene       Date:  2021-03-01       Impact factor: 9.867

4.  Reproducing abnormal cholesterol biosynthesis as seen in the Smith-Lemli-Opitz syndrome by inhibiting the conversion of 7-dehydrocholesterol to cholesterol in rats.

Authors:  G Xu; G Salen; S Shefer; G C Ness; T S Chen; Z Zhao; G S Tint
Journal:  J Clin Invest       Date:  1995-01       Impact factor: 14.808

5.  7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome.

Authors:  B U Fitzky; F F Moebius; H Asaoka; H Waage-Baudet; L Xu; G Xu; N Maeda; K Kluckman; S Hiller; H Yu; A K Batta; S Shefer; T Chen; G Salen; K Sulik; R D Simoni; G C Ness; H Glossmann; S B Patel; G S Tint
Journal:  J Clin Invest       Date:  2001-09       Impact factor: 14.808

6.  Multi-omics investigation reveals benzalkonium chloride disinfectants alter sterol and lipid homeostasis in the mouse neonatal brain.

Authors:  Josi M Herron; Kelly M Hines; Hideaki Tomita; Ryan P Seguin; Julia Yue Cui; Libin Xu
Journal:  Toxicol Sci       Date:  2019-06-14       Impact factor: 4.849

Review 7.  Holoprosencephaly: a paradigm for the complex genetics of brain development.

Authors:  E Roessler; M Muenke
Journal:  J Inherit Metab Dis       Date:  1998-08       Impact factor: 4.982

8.  Abnormal cholesterol biosynthesis in the Smith-Lemli-Opitz and the lethal acrodysgenital syndromes.

Authors:  V Cormier-Daire; C Wolf; A Munnich; M Le Merrer; A Nivelon; D Bonneau; H Journel; F Fellmann; F Chevy; C Roux
Journal:  Eur J Pediatr       Date:  1996-08       Impact factor: 3.183

9.  Brain and optic system pathology in hypocholesterolemic dogs treated with a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

Authors:  P H Berry; J S MacDonald; A W Alberts; S Molon-Noblot; J S Chen; C Y Lo; M D Greenspan; H Allen; G Durand-Cavagna; R Jensen
Journal:  Am J Pathol       Date:  1988-09       Impact factor: 4.307

10.  Mutations in the human sterol delta7-reductase gene at 11q12-13 cause Smith-Lemli-Opitz syndrome.

Authors:  C A Wassif; C Maslen; S Kachilele-Linjewile; D Lin; L M Linck; W E Connor; R D Steiner; F D Porter
Journal:  Am J Hum Genet       Date:  1998-07       Impact factor: 11.025
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