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Literature DB >> 6159307

Specific and non-specific suppressor cell activity in NZB mice.

Abstract

Non-specific and specific suppressor cell activity has been examined in both young and old NZB mice and compared to normal CBA mice. Both young and old NZB mice are shown to be able to generate antigen non-specific and specific suppressor cells in response to Con A and rat RBC respectively. In addition, antigen-specific suppressor cells which suppress the experimental induction of red cell autoantibodies do not influence the spontaneous development or course of autoimmune haemolytic anaemia. Subsequent experiments showed that this is probably due to differences in specificity of induced and spontaneous autoantibodies.

Entities: Disease Species

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Year: 1980 PMID： 6159307 PMCID： PMC1458064

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

21 in total

1. Induction of red cell autoantibodies in normal mice.

Authors: J H Playfair; S Marshall-Clarke
Journal: Nat New Biol Date: 1973-06-13

2. Enhanced antibody response of mice to polyinosinic-polycytidylic acid by antithymocyte serum and its age-dependent loss in NZB-W mice.

Authors: T M Chused; A D Steinberg; L M Parker
Journal: J Immunol Date: 1973-07 Impact factor: 5.422

4. Haemolytic disease in mice induced by transplantation of hybridoma cells secreting monoclonal anti-erythrocyte autoantibodies.

Authors: L A Cooke; N A Staines; A Morgan; C Moorhouse; G Harris
Journal: Immunology Date: 1982-11 Impact factor: 7.397

Review 5. Regulatory T cells essential to prevent the loss of self-tolerance in murine models of erythrocyte-specific autoantibody responses.

Authors: Catherine E Calkins
Journal: Immunol Res Date: 2011-12 Impact factor: 2.829

5 in total

Specific and non-specific suppressor cell activity in NZB mice.

1. Induction of red cell autoantibodies in normal mice.

2. Enhanced antibody response of mice to polyinosinic-polycytidylic acid by antithymocyte serum and its age-dependent loss in NZB-W mice.

3. A rapid method for the isolation of functional thymus-derived murine lymphocytes.

4. Autoimmune haemolytic anaemia induced in mice immunized with rat erythrocytes.

5. Further improvements in the plaque technique for detecting single antibody-forming cells.

6. Decline in suppressor T cell function with age in female NZB mice.

7. Loss with age in NZB-W mice of thymic suppressor cells in the graft-vs-host reaction.

8. Relative inability to induce tolerance in adult NZB and NZB-NZW F1 mice.

9. The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response.

10. Comparison of the immune responsiveness of NZB and NZB X NZW F1 hybrid mice with that of other strains of mice.

1. Lack of autoantigen-specific splenic suppressor cells in mice with an X-linked B-lymphocyte defect.

2. The role of suppressor T cells in the expression of autoimmune haemolytic anaemia in NZB mice.

3. Sex differences in the regulation of experimentally induced autoantibodies in (NZB x NZW)F1 mice.

4. Haemolytic disease in mice induced by transplantation of hybridoma cells secreting monoclonal anti-erythrocyte autoantibodies.

Review 5. Regulatory T cells essential to prevent the loss of self-tolerance in murine models of erythrocyte-specific autoantibody responses.