Literature DB >> 6158881

Acute pancreatitis. Experimental evaluation of steroid, albumin and trasylol therapy.

T Kimura, G D Zuidema, J L Cameron.   

Abstract

The efficacy of steroids, albumin and Trasylol administration in the treatment of experimental pancreatitis was evaluated. An isolated, ex vivo, perfused canine pancreas preparation was used and pancreatitis was initiated by free fatty acid infusion. Steroid administration worsened pancreatitis, Trasylol had no effect, and albumin was markedly effective in ameliorating pancreatitis. These results were interpreted as evidence against enzyme extravasation and for capillary injury as the initial step in the pathogenesis of pancreatitis.

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Year:  1980        PMID： 6158881     DOI： 10.1016/0002-9610(80)90178-6

Source DB:  PubMed          Journal:  Am J Surg        ISSN： 0002-9610            Impact factor:   2.565


  9 in total

1.  Efficacy of glucocorticoids in rodents of severe acute pancreatitis: a meta-analysis.

Authors:  Min Yu; Zhen Yang; Yin Zhu; Nonghua Lu
Journal:  Int J Clin Exp Pathol       Date:  2014-06-15

2.  Steroids do not alter pancreatic blood supply in hypovolemic dogs: implications on steroid action in acute pancreatitis.

Authors:  J H Robert; A E Toledano; L S Toth; G Premus; D A Dreiling
Journal:  Int J Pancreatol       Date:  1988-12

3.  Effect of drugs on the pulmonary changes in experimental acute pancreatitis in the rat.

Authors:  A R Berry; T V Taylor
Journal:  Gut       Date:  1982-06       Impact factor: 23.059

4.  The pathogenesis of acute pancreatitis. The source and role of oxygen-derived free radicals in three different experimental models.

Authors:  H Sanfey; G B Bulkley; J L Cameron
Journal:  Ann Surg       Date:  1985-05       Impact factor: 12.969

5.  Total parenteral nutrition during acute pancreatitis: clinical experience with 156 patients.

Authors:  A P Robin; R Campbell; C K Palani; K Liu; P E Donahue; L M Nyhus
Journal:  World J Surg       Date:  1990 Sep-Oct       Impact factor: 3.352

6.  Benefits of various dextrans after delayed therapy in necrotizing pancreatitis of the rat.

Authors:  J Schmidt; K Huch; K Mithöfer; H G Hotz; H P Sinn; H J Buhr; A L Warshaw; C Herfarth; E Klar
Journal:  Intensive Care Med       Date:  1996-11       Impact factor: 17.440

7.  Effects of intravenous fat emulsion administration on exocrine and endocrine pancreatic function.

Authors:  S Matsuno; E Miyashita; K Sasaki; T Sato
Journal:  Jpn J Surg       Date:  1981

8.  Experimental gallstone pancreatitis. Pathogenesis and response to different treatment modalities.

Authors:  P J Broe; J L Cameron
Journal:  Ann Surg       Date:  1982-05       Impact factor: 12.969

9.  The role of oxygen-derived free radicals in the pathogenesis of acute pancreatitis.

Authors:  H Sanfey; G B Bulkley; J L Cameron
Journal:  Ann Surg       Date:  1984-10       Impact factor: 12.969
  9 in total

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