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Literature DB >> 6158734

Substance P: a powerful intestinal vasodilator in the pig.

Abstract

In anaesthetized young pigs the influence of intra-arterial infusions of Substance P (SP) on mesenteric vascular resistance is studied, both before and after serotoninergic and nervous conductivity blockade by dihydroergotamine (DHE) and tetrodotoxin (TTX). SP has a strong dilator effect on pig mesenterial vessels, which is not significantly modified by DHE or TTX; presumably SP acts directly on the vascular smooth muscle. By comparing the threshold level of SP with that of other intestinal vasdodilators, it may be concluded that SP is the most powerful intestinal vasodilator so far extperimented in the pig.

Entities: Chemical Species

Mesh：

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Year: 1980 PMID： 6158734 DOI： 10.1007/BF00587480

Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657

6 in total

1. [The Goettingen miniature swine as an experimental animal. 1. Review of literature, breeding and handling, cardiovascular parameters].

Authors: R Beglinger; M Becker; E Eggenberger; C Lombard
Journal: Res Exp Med (Berl) Date: 1975-09-24

Substance P: a powerful intestinal vasodilator in the pig.

1. [The Goettingen miniature swine as an experimental animal. 1. Review of literature, breeding and handling, cardiovascular parameters].

2. The cardivascular effects of substance P in the chicken.

3. Pharmacology of substance P.

4. An unidentified depressor substance in certain tissue extracts.

5. Effect of substance P on various vascular beds in the dog.

6. Influence of primary prostaglandins, prostacyclin and arachidonic acid on mesenteric hemodynamics in the pig.

1. Increased myometrial blood flow evoked by substance P.

2. The effects of substance P on smooth muscle cells and on neuro-effector transmission in the guinea-pig ileum.

3. Possible involvement of capsaicin-sensitive sensory nerves in the regulation of intestinal blood flow in the dog.

4. The effect of carcinoid levels of serotonin and substance P on hemodynamics.

5. Autonomic, sensory, and motor dysfunction following intrathecal administration of three substance P antagonists.

6. Mesenteric traction syndrome in pigs: A single-blinded, randomized controlled trial.