Literature DB >> 6158569

Synthesis of potential anticonvulsants: condensation of isatins with acetone and related ketones.

F D Popp, R Parson, B E Donigan.   

Abstract

Substituted isatins were condensed with acetone and other ketones to give analogs of 3-hydroxy-3-acetonyloxindole. Some of these alcohols were dehydrated. Several compounds with anticonvulsant activity were obtained.

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Year:  1980        PMID： 6158569     DOI： 10.1002/jps.2600691035

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  4 in total

1.  Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2.

Authors:  Cornelius Klöck; Xi Jin; Kihang Choi; Chaitan Khosla; Peter B Madrid; Andrew Spencer; Brian C Raimundo; Paul Boardman; Guido Lanza; John H Griffin
Journal:  Bioorg Med Chem Lett       Date:  2010-12-16       Impact factor: 2.823

2.  Synthesis and evaluation of 1,3 di-substituted schiff, mannich bases and spiro isatin derivatives.

Authors:  P Mondal; M Banerjee; S Jana; A Bose
Journal:  J Young Pharm       Date:  2010-04

3.  Potential antimicrobial agents--I: Structural modifications and antimicrobial activity of some isatin derivatives.

Authors:  S Ali; M Alam
Journal:  Arch Pharm Res       Date:  1994-04       Impact factor: 4.946

4.  Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands.

Authors:  Lars Richter; Chris de Graaf; Werner Sieghart; Zdravko Varagic; Martina Mörzinger; Iwan J P de Esch; Gerhard F Ecker; Margot Ernst
Journal:  Nat Chem Biol       Date:  2012-03-25       Impact factor: 15.040
  4 in total

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