Literature DB >> 6158066

Tryptophol-induced change in Brain 5-hydroxytryptamine Metabolism.

R Fukumori, A Minegishi, T Satoh, H Kitagawa, S Yanaura.   

Abstract

The effects of tryptoiphol (TOL) on brain 5-hydroxytryptamine (5-HT) metabolism were studied. After TOL injection (200 mg/kg IP), brain 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) levels were increased, 5-HT synthesis rate was decreased, and monoamine oxidase (MAO) activity remained unchanged. Pretreatment of mice with p-chlorophenylalanine (PCPA), a potent inhibitor of 5-HT synthesis, did not affect the anticonvulsant action of TOL.. These results suggest that alteration of 5-HT metabolism after TOL injection is not directly related to the anticonvulsant action of TOL

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Year:  1980        PMID： 6158066     DOI： 10.1007/BF00433089

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  15 in total

1.  Inhibition of aldehyde reductase isoenzymes in human and rat brain.

Authors:  M M Ris; R A Deitrich; J P Von Wartburg
Journal:  Biochem Pharmacol       Date:  1975-10-15       Impact factor: 5.858

2.  Altered 5-HT metabolism with clonazepam, diazepam and diphenylhydantoin.

Authors:  P Jenner; D Chadwick; E H Reynolds; C D Marsden
Journal:  J Pharm Pharmacol       Date:  1975-09       Impact factor: 3.765

3.  Effect of tryptophol on pentylenetetrazol and picrotoxin induced convulsion in mice.

Authors:  T Satoh; R Fukumori; I Nakagawa; A Minegishi; H Kitagawa; S Yanaura
Journal:  Life Sci       Date:  1979-05-28       Impact factor: 5.037

4.  Susceptibility of brain aldehyde metabolizing enzymes to pargyline, disulfiram and diethylmaleate in vivo in rats.

Authors:  A Minegishi; T Satoh; R Fukumori; H Kitagawa; S Yanaura
Journal:  Life Sci       Date:  1979-03-19       Impact factor: 5.037

5.  Benzodiazepines and barbiturates: turnover changes in central 5-hydroxytryptamine pathways.

Authors:  P Lidbrink; H Corrodi; K Fuxe
Journal:  Eur J Pharmacol       Date:  1974-04       Impact factor: 4.432

6.  Central monoamines and convulsine thresholds in mice and rats.

Authors:  M Kilian; H H Frey
Journal:  Neuropharmacology       Date:  1973-07       Impact factor: 5.250

7.  p-Chlorophenylalanine: a specific depletor of brain serotonin.

Authors:  B K Koe; A Weissman
Journal:  J Pharmacol Exp Ther       Date:  1966-12       Impact factor: 4.030

8.  Stimulation of serotonin synthesis by lithium.

Authors:  J Perez-Cruet; A Tagliamonte; P Tagliamonte; G L Gessa
Journal:  J Pharmacol Exp Ther       Date:  1971-08       Impact factor: 4.030

9.  Induction of NADH-dependent aldehyde reductase by successive administration of barbiturates in rat brain.

Authors:  T Satoh; R Fukumori; A Minegishi; H Kitagawa; S Yanaura
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1979-02

10.  Changes in serotonin turnover and the brain sensitivity to barbiturates by disulfiram treatment in rats.

Authors:  A Minegishi; R Fukumori; T Satoh; H Kitagawa; S Yanaura
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1979-05
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  1 in total

1.  Effect of disulfiram in combination with L-tryptophan and lithium on pentylenetetrazol-induced seizure.

Authors:  A Minegishi; R Fukumori; T Satoh; H Kitagawa
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530
  1 in total

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