| Literature DB >> 6157774 |
E A Goldings, P L Cohen, S F McFadden, M Ziff, E S Vitetta.
Abstract
Hapten-specific tolerance was induced in vitro by trinitrophenyl-human gamma globulin (TNP32HGG) to a comparable degree in B cells from adult autoimmune (NZB X NZW)F1 (B/W) mice and normal BDF1, CBA/J, and DBA/1J mice. When a lower epitope density tolerogen (TNP7HGG) was used, B/W mice were significantly less sensitive than normal mice to the induction of B cell tolerance. This finding of defective B cell tolerance in adult B/W mice is consistent with previous reports that document other B cell abnormalities that may relate to the expression of autoimmune disease.Entities:
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Year: 1980 PMID： 6157774 PMCID： PMC2185913 DOI： 10.1084/jem.152.3.730
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307