| Literature DB >> 6157015 |
J P Nautsch, L H Rolf, G G Brune.
Abstract
The purpose of this study was to develop a rapid GLC method for the simultaneous determination of the following anticonvulsants: Carbamazepine, Diphenylhydantoin, Phenobarbital, and Primidone. Using a metal column (OV-17) with flash heater methylation as well as high N2 flow-rate, a quantitative methylation of the above anticonvulsants was obtained. A selective temperature program proved to be the decisive factor in separating the various methylated anticonvulsants. The GLC program was completed within 13 min. This method permits a rapid, simultanous and quantitative determination of various important anticonvulsants.Entities:
Mesh：
Substances：
Year: 1980 PMID： 6157015 DOI： 10.1007/BF00313186
Source DB: PubMed Journal: J Neurol ISSN： 0340-5354 Impact factor: 4.849