Literature DB >> 6156949

Elevated serum levels of pancreatic secretory proteins in cigarette smokers after secretin stimulation.

G Balldin, A Borgström, A Eddeland, S Genell, L Hagberg, K Ohlsson.   

Abstract

The secretory pancreatic proteins in serum were analyzed in a group of cigarette smokers and a control group of nonsmokers before and after intravenous secretin stimulation. None of these persons had any signs of pancreatic disease. In the control group, serum total amylase activity, pancreatic isoamylase, cationic trypsinogen, and pancreatic secretory trypsin inhibitor concentrations varied within the normal range before and after secretin injection. In contrast, the concentrations of these pancreatic proteins in all the cigarette smokers elevated from normal to abnormally high serum concentrations after secretin stimulation. The results indicate a probable toxic effect of cigarette smoking on the exocrine pancreas.

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Year:  1980        PMID： 6156949      PMCID： PMC371517          DOI： 10.1172/JCI109829

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


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Authors:  A Eddeland; K Ohlsson
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