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Literature DB >> 6156909

Effects of molecular weight of dextran on the adherence of Streptococcus sanguis to damaged heart valves.

Abstract

Dextran-producing streptococci such as Streptococcus sanguis are the organisms most frequently associated with infective endocarditis in humans. A series of experiments was designed to study how the molecular weight of dextrans affects the adherence of an endocarditis strain of S. sanguis to canine heart valves covered with platelets and fibrin. The data indicated that this adherence was dependent on dextrans of high molecular weight, such as dextran T-2000 or glucans isolated from S. sanguis or S. mutans. The adherence properties of the strain studied were not modified by prior exposure of the bacterial cells of valve leaflets to high-molecular-weight dextrans. Preexposure of bacterial cells or valve leaflets to low-molecular-weight dextrans decreased their adherence. Low-molecular-weight dextrans interfered with adherence of dextran-positive strains to damaged heart valves.

Entities: Chemical Disease Species

Mesh：

Substances：
Dextrans

Year: 1980 PMID： 6156909 PMCID： PMC551065 DOI： 10.1128/iai.29.1.1-7.1980

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

21 in total

1. Growth of several cariogenic strains of oral streptococci in a chemically defined medium.

Authors: B Terleckyj; N P Willett; G D Shockman
Journal: Infect Immun Date: 1975-04 Impact factor: 3.441

2. Streptococcus mutans dextransucrase: mode of interaction with high-molecular-weight dextran and role in cellular aggregation.

Authors: G R Germaine; C F Schachtele
Journal: Infect Immun Date: 1976-02 Impact factor: 3.441

3. Properties of Streptococcus mutans grown in a synthetic medium: binding of glucosyltransferase and in vitro adherence, and binding of dextran/glucan and glycoprotein and agglutination.

Authors: C D Wu-Yuan; S Tai; H D Slade
Journal: Infect Immun Date: 1979-03 Impact factor: 3.441

4. Adherence of bacteria to heart valves in vitro.

Authors: K Gould; C H Ramirez-Ronda; R K Holmes; J P Sanford
Journal: J Clin Invest Date: 1975-12 Impact factor: 14.808

5. Dextran/glucan binding by Streptococcus mutans: the role of molecular size and binding site in agglutination.

Authors: C D Wu-Yuan; S Tai; H D Slade
Journal: Adv Exp Med Biol Date: 1978 Impact factor: 2.622

6. Bacterial adherence in the pathogenesis of endocarditis. Interaction of bacterial dextran, platelets, and fibrin.

Authors: W M Scheld; J A Valone; M A Sande
Journal: J Clin Invest Date: 1978-05 Impact factor: 14.808

7. Streptococci and aerococci associated with systemic infection in man.

Authors: M T Parker; L C Ball
Journal: J Med Microbiol Date: 1976-08 Impact factor: 2.472

8. Dextran-mediated interbacterial aggregation between dextran-synthesizing streptococci and Actinomyces viscosus.

Authors: G Bourgeau; B C McBride
Journal: Infect Immun Date: 1976-04 Impact factor: 3.441

9. Effect of sucrose in culture media on the location of glucosyltransferase of Streptococcus mutans and cell adherence to glass surfaces.

Authors: S Hamada; M Torii
Journal: Infect Immun Date: 1978-06 Impact factor: 3.441

6. Complete genome and transcriptomes of Streptococcus parasanguinis FW213: phylogenic relations and potential virulence mechanisms.

Authors: Jianing Geng; Cheng-Hsun Chiu; Petrus Tang; Yaping Chen; Hui-Ru Shieh; Songnian Hu; Yi-Ywan M Chen
Journal: PLoS One Date: 2012-04-18 Impact factor: 3.240

6 in total

Effects of molecular weight of dextran on the adherence of Streptococcus sanguis to damaged heart valves.

1. Growth of several cariogenic strains of oral streptococci in a chemically defined medium.

2. Streptococcus mutans dextransucrase: mode of interaction with high-molecular-weight dextran and role in cellular aggregation.

3. Properties of Streptococcus mutans grown in a synthetic medium: binding of glucosyltransferase and in vitro adherence, and binding of dextran/glucan and glycoprotein and agglutination.

4. Adherence of bacteria to heart valves in vitro.

5. Dextran/glucan binding by Streptococcus mutans: the role of molecular size and binding site in agglutination.

6. Bacterial adherence in the pathogenesis of endocarditis. Interaction of bacterial dextran, platelets, and fibrin.

7. Streptococci and aerococci associated with systemic infection in man.

8. Dextran-mediated interbacterial aggregation between dextran-synthesizing streptococci and Actinomyces viscosus.

9. Effect of sucrose in culture media on the location of glucosyltransferase of Streptococcus mutans and cell adherence to glass surfaces.

10. Adherence of glucan-positive and glucan-negative streptococcal strains to normal and damaged heart valves.

1. Role of adherence in infective endocarditis.

2. Phenotypic characterization of Streptococcus sanguis virulence factors associated with bacterial endocarditis.

3. Glucosyltransferase mediates adhesion of Streptococcus gordonii to human endothelial cells in vitro.

4. Exopolysaccharide production by viridans streptococci in experimental endocarditis.

5. Aggregation of human platelets and adhesion of Streptococcus sanguis.

6. Complete genome and transcriptomes of Streptococcus parasanguinis FW213: phylogenic relations and potential virulence mechanisms.