Literature DB >> 6156844

Antibodies to immunoglobulin heavy chain variable regions protect helper cells from specific suicide by radiolabeled antigen.

J Puri, Y Ben-Neriah, D Givol, P Lonai.   

Abstract

The antigen-binding receptor of helper T cells was studied by radioactive antigen-caused suicide in vitro. Purified antibodies to immunoglobulin variable regions, obtained from sera of rabbits immunized with isolated VH and VL fragments of mouse myeloma proteins (MOPC 315, XRPC 25), were used to inhibit the binding of radiotoxic antigen. Anti-VH, but not anti-V lambda or anti-V chi inhibited suicide of carrier-primed cells.

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Year:  1980        PMID： 6156844     DOI： 10.1002/eji.1830100411

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  5 in total

1.  H-2-restricted antigen binding by a hybridoma clone that produces antigen-specific helper factor.

Authors:  P Lonai; J Puri; G Hämmerling
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205

2.  H-2-restricted helper factor secreted by clone hybridoma cells.

Authors:  P Lonai; J Puri; S Bitton; Y Ben-Neriah; D Givol; G J Hämmerling
Journal:  J Exp Med       Date:  1981-09-01       Impact factor: 14.307

3.  Immunoglobulin VH determinants defined by monoclonal antibodies.

Authors:  H Kubagawa; M Mayumi; J F Kearney; M D Cooper
Journal:  J Exp Med       Date:  1982-10-01       Impact factor: 14.307

4.  Two separate genes regulate self-Ia and carrier recognition in H-2-restricted helper factors secreted by hybridoma cells.

Authors:  P Lonai; S Bitton; H F Savelkoul; J Puri; G J Hämmerling
Journal:  J Exp Med       Date:  1981-12-01       Impact factor: 14.307

5.  Use of somatic cell genetics to study chromosomes contributing to antigen plus I recognition by T cell hybridomas.

Authors:  P Marrack; J Kappler
Journal:  J Exp Med       Date:  1983-02-01       Impact factor: 14.307
  5 in total

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