Long-term effects of minoxidil therapy on renal function of patients with refractory hypertension: the significance of albuminuria.

The addition of minoxidil therapy reduced blood pressure effectively for 6--52 months (average, 24) in 25 of 28 patients with refractory hypertension. One patient was nonresponsive; 2 were noncompliant. Patients who had a serum creatinine up to 4 mg% and greater than 750 mg of albuminuria per day had further deterioration of renal function of 5.3 +/- 1.4% per month compared to that of 0.2 +/- 0.4% per month in patients without albuminuria (p less th5% was not as helpful predicting preservation of renal function in patients with refractory hypertension after adding minoxidil as was the absence of albuminuria.