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Literature DB >> 6155766

Inhibition of cholinergic histamine release in rat mast cells.

R Fantozzi, E Masini, P Blandina, T Bani-Sacchi, L Zilletti, P F Mannaioni.

Abstract

Adrenaline inhibits the acetylcholine-evoked histamine release from isolated purified rat mast cells, in a dose-dependent fashion. The inhibitory effect of adrenaline is reversed by preincubating the cells with a beta-blocker, aprenolol, but not by preincubating them with an alpha-blocker, phentolamine. These results were confirmed by observations using an electron microscope and they suggest that adrenaline inhibits the cholinergic histamine release from rat mast cells acting upoon beta-receptors.

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Year: 1980 PMID： 6155766 DOI： 10.1007/BF02024196

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

7 in total

3 in total

1. Comparative studies of mast cells from normal (non-immunized) and actively sensitized dogs.

Authors: J Heymanns; H Behrendt; W Schmutzler
Journal: Agents Actions Date: 1982-04

2. Mast cell receptors controlling histamine release: influences on the mode of action of drugs used in the treatment of adverse drug reactions.

Authors: E Masini; P Blandina; P F Mannaioni
Journal: Klin Wochenschr Date: 1982-09-01

3. Presence of functionally active beta-adrenoceptors in rat mast cells. Correlation between (--)[3H]-dihydroalprenolol binding and inhibition of histamine release.

Authors: E Masini; R Fantozzi; P Blandina; A Galli; T Bani-Sacchi; A Giotti; L Zilletti; P F Mannaioni
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1982-12 Impact factor: 3.000

3 in total

Inhibition of cholinergic histamine release in rat mast cells.

1. A procedure for the determination of histamine.

2. A method for the fluorometric assay of histamine in tissues.

3. Cholinergic histamine release: evidence of muscarinic receptors in rat mast cells [proceedings].

Review 4. Modulation of the spontaneous histamine release by adrenergic and cholinergic drugs.

5. Inhibitory role of cyclic adenosine 3' 5'-monophosphate in histamine release from rat peritoneal mast cells in vitro.

6. Release of histamine from rat mast cells by acetylcholine.

7. Modulation of cyclic AMP in purified rat mast cells. I. Responses to pharmacologic, metabolic, and physical stimuli.

1. Comparative studies of mast cells from normal (non-immunized) and actively sensitized dogs.

2. Mast cell receptors controlling histamine release: influences on the mode of action of drugs used in the treatment of adverse drug reactions.

3. Presence of functionally active beta-adrenoceptors in rat mast cells. Correlation between (--)[3H]-dihydroalprenolol binding and inhibition of histamine release.