Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate.

× No keyword cloud information.

24 in total

Review 1. Polyglutamation of methotrexate. Is methotrexate a prodrug?

Authors: B A Chabner; C J Allegra; G A Curt; N J Clendeninn; J Baram; S Koizumi; J C Drake; J Jolivet
Journal: J Clin Invest Date: 1985-09 Impact factor: 14.808

Review 2. Will pharmacogenetics allow better prediction of methotrexate toxicity and efficacy in patients with rheumatoid arthritis?

Authors: P Ranganathan; S Eisen; W M Yokoyama; H L McLeod
Journal: Ann Rheum Dis Date: 2003-01 Impact factor: 19.103

3. Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow.

Authors: S Koizumi; G A Curt; R L Fine; J D Griffin; B A Chabner
Journal: J Clin Invest Date: 1985-03 Impact factor: 14.808

Review 4. Pharmacogenetics: implications for therapy in rheumatic diseases.

Authors: Lesley Davila; Prabha Ranganathan
Journal: Nat Rev Rheumatol Date: 2011-08-09 Impact factor: 20.543

5. Novel pyrrolo[2,3-d]pyrimidine antifolate TNP-351: cytotoxic effect on methotrexate-resistant CCRF-CEM cells and inhibition of transformylases of de novo purine biosynthesis.

Authors: F Itoh; O Russello; H Akimoto; G P Beardsley
Journal: Cancer Chemother Pharmacol Date: 1994 Impact factor: 3.333

6. Insulin effects on methotrexate polyglutamate synthesis and enzyme binding in cultured human breast cancer cells.

Authors: R L Schilsky; F S Ordway
Journal: Cancer Chemother Pharmacol Date: 1985 Impact factor: 3.333

7. Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.

Authors: C J Allegra; J C Drake; J Jolivet; B A Chabner
Journal: Proc Natl Acad Sci U S A Date: 1985-08 Impact factor: 11.205

8. Effects of 5,8-dideazaisopteroylglutamate (IAHQ) on L1210 leukemia in mice when given alone and in combination with methotrexate, probenecid, or verapamil.

Authors: J B Hynes; A B Smith; G R Gale
Journal: Cancer Chemother Pharmacol Date: 1986 Impact factor: 3.333

9. Synthesis, retention, and biological activity of methotrexate polyglutamates in cultured human breast cancer cells.

Authors: J Jolivet; R L Schilsky; B D Bailey; J C Drake; B A Chabner
Journal: J Clin Invest Date: 1982-08 Impact factor: 14.808

10. Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase.

Authors: J Jolivet; B A Chabner
Journal: J Clin Invest Date: 1983-09 Impact factor: 14.808