Literature DB >> 6155287

The effects of beta-sympathomimetic amines and phosphodiesterase inhibitors on electrophysiological parameters in Purkinje fibres.

J J Schulze, H Averesch.   

Abstract

Dose-dependent responses to L-isoprenaline of spontaneous activity and plateau height in Purkinje fibres can be mimicked closely by the PDE-inhibitor IBMX. Simultaneous applications of sympathomimetic amines and IBMX result in potentiated responses. The results support the hypothesis that cyclic-AMP is the common mediator of positive chronotropic and inotropic effects induced by beta-sympathomimetic amines.

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Year:  1980        PMID： 6155287     DOI： 10.1007/BF01965819

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  4 in total

1.  Effects of several phosphodiesterase-inhibitors on guinea-pig myocardium.

Authors:  M Korth
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-03       Impact factor: 3.000

2.  The effects of isoprenaline and a new beta-sympathomimetic amine upon spontaneous activity, diastolic depolarization and plateau height in cardiac Purkinje fibres.

Authors:  W Grabowski; H C Lüttgau; J J Schulze
Journal:  Br J Pharmacol       Date:  1978-07       Impact factor: 8.739

3.  Localization of beta adrenergic receptors, and effects of noradrenaline and cyclic nucleotides on action potentials, ionic currents and tension in mammalian cardiac muscle.

Authors:  H Reuter
Journal:  J Physiol       Date:  1974-10       Impact factor: 5.182

4.  Effects of epinephrine on the pacemaker potassium current of cardiac Purkinje fibers.

Authors:  R W Tsien
Journal:  J Gen Physiol       Date:  1974-09       Impact factor: 4.086
  4 in total

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