Literature DB >> 6155271

Delayed-type hypersensitivity induced by antigen-pulsed, bone marrow-derived macrophages.

P L Mottram, J F Miller.   

Abstract

Mouse bone marrow cells, cultured in specifically conditioned medium, were found to be virtually pure macrophages after 7 days. When pulsed with antigen, these cells induced and elicited delayed-type hypersensitivity (DTH) with the same efficiency and major histocompatibility complex restrictions as antigen-pulsed peritoneal exudate cells. Both of these macrophage populations had 20% Ia+ cells, as measured by complement-mediated cytotoxicity. When most of the Ia+ cells were removed, the remaining antigen-pulsed macrophages could not elicit DTH in sensitized mice.

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Year:  1980        PMID： 6155271     DOI： 10.1002/eji.1830100302

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  9 in total

Review 1.  Macrophages and antitumor reactions.

Authors:  W Den Otter; H F Dullens; R A De Weger
Journal:  Cancer Immunol Immunother       Date:  1983       Impact factor: 6.968

2.  Evidence for depletion of Ia+ macrophages and associated immunosuppression in African trypanosomiasis.

Authors:  O Bagasra; R F Schell; J L Le Frock
Journal:  Infect Immun       Date:  1981-04       Impact factor: 3.441

3.  I-A subregion control of the transfer of delayed type hypersensitivity (DTH).

Authors:  M S Sandrin; I F McKenzie
Journal:  Immunogenetics       Date:  1982       Impact factor: 2.846

4.  Ability of macrophages to process and present Treponema pallidum Bosnia A strain antigens in experimental syphilis of syrian hamsters.

Authors:  O Bagasra; I Damjanov
Journal:  Infect Immun       Date:  1982-04       Impact factor: 3.441

5.  Genetic regulation of delayed-type hypersensitivity responses to poly (Tyr,Glu)-poly(DLAla)--poly(Lys): expression of the genetic defect in the induction and manifestation phases in H-2s and H-2f mice.

Authors:  G Strassman; E Mozes; Z Eshhar
Journal:  Immunology       Date:  1982-03       Impact factor: 7.397

6.  The inductive requirements for the primary in vitro generation of delayed-type hypersensitivity response to influenza virus in mice.

Authors:  K N Leung; N K Mak; G L Ada
Journal:  Immunology       Date:  1981-09       Impact factor: 7.397

7.  Adoptive transfer of suppression of arthritis in the mouse model of collagen-induced arthritis. Evidence for a type II collagen-specific suppressor T cell.

Authors:  T F Kresina; R W Moskowitz
Journal:  J Clin Invest       Date:  1985-06       Impact factor: 14.808

8.  The induction of lymphocytes with the capacity to render macrophages cytotoxic in an allogeneic murine system.

Authors:  R A De Weger; E Pels; W Den Otter
Journal:  Immunology       Date:  1982-11       Impact factor: 7.397

9.  [Macrophage precursors as cytotoxic effector cells (author's transl)].

Authors:  M L Lohmann-Matthes; M Zähringer
Journal:  Blut       Date:  1981-05
  9 in total

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