Literature DB >> 6154638

Lymphocyte proliferation in Down's syndrome measured by sister chromatid differential staining.

P E Crossen, W F Morgan.   

Abstract

Lymphocyte proliferation in PHA stimulated cultures from Down's syndrome patients and normals was measured by the BrdU/Giemsa method for demonstrating sister chromatid differential staining. Both Down's syndrome patients and normals had 1st, 2nd and 3rd divisions present. However, Down's syndrome patients had more 3rd division metaphases and fewer 2nd division metaphases than the normals. There was no difference in the mitotic index between the two groups.

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Year:  1980        PMID： 6154638     DOI： 10.1007/BF00287048

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  17 in total

1.  Blaze drying, by igniting the fixative, for improved spreads of chromosomes in leucocytes.

Authors:  R G SCHERZ
Journal:  Stain Technol       Date:  1962-11

2.  Cell cycle analysis and properties of two sub-populations in PHA responding lymphocytes. A comparison of 21-trisomic and normal cells.

Authors:  K Kishi
Journal:  Jinrui Idengaku Zasshi       Date:  1977-06

3.  Hyperblastic response to dilute P.H.A. in Down's syndrome.

Authors:  H Hayakawa; I Matsui; M Higurashi; N Kobayashi
Journal:  Lancet       Date:  1968-01-13       Impact factor: 79.321

4.  Enzyme studies during lymphocyte stimulation with phytohemagglutinin in Down's syndrome.

Authors:  H L Nadler; P Monteleone; D Y Hsia
Journal:  Life Sci       Date:  1967-09-15       Impact factor: 5.037

5.  Sister chromatid exchanges induced by light flashes to 5-bromodeoxyuridine- and 5-iododeoxyuridine substituted Chinese hamster chromosomes.

Authors:  T Ikushima; S Wolff
Journal:  Exp Cell Res       Date:  1974-07       Impact factor: 3.905

6.  Response to stimulation in vitro of lymphocytes from patients with Down's syndrome.

Authors:  I Fowler; D R Hollingsworth; H Traurig
Journal:  Proc Soc Exp Biol Med       Date:  1973-11

7.  Transformation of blood lymphocytes in ataxia telangiectasia. Dose and time response to phytohemagglutinin.

Authors:  D A Rigas; V V Tisdale; F Hecht
Journal:  Int Arch Allergy Appl Immunol       Date:  1970

8.  Proliferation of PHA-stimulated lymphocytes measured by combined autoradiography sister chromatid differential staining.

Authors:  P E Crossen; W F Morgan
Journal:  Exp Cell Res       Date:  1979-02       Impact factor: 3.905

9.  Proliferation of PHA- and PWM-stimulated lymphocytes measured by sister chromatid differential staining.

Authors:  P E Crossen; W F Morgan
Journal:  Cell Immunol       Date:  1977-08       Impact factor: 4.868

10.  Impaired Lymphocyte Transformation and Delayed Hypersensitivity in Sjögren's Syndrome.

Authors:  B G Leventhal; D S Waldorf; N Talal
Journal:  J Clin Invest       Date:  1967-08       Impact factor: 14.808
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  5 in total

1.  Chromosomal radiosensitivity of Down syndrome lymphocytes at different stages of the cell cycle.

Authors:  H M Shafik; W W Au; M S Legator
Journal:  Hum Genet       Date:  1988-01       Impact factor: 4.132

2.  Proliferation of PPD-stimulated lymphocytes measured by sister chromatoid differential staining.

Authors:  P E Crossen; W F Morgan
Journal:  Clin Exp Immunol       Date:  1981-09       Impact factor: 4.330

3.  Variation in the sensitivity of human lymphocytes to DNA-damaging agents measured by sister chromatid exchange frequency.

Authors:  P E Crossen
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

4.  Trisomy correction in Down syndrome induced pluripotent stem cells.

Authors:  Li B Li; Kai-Hsin Chang; Pei-Rong Wang; Roli K Hirata; Thalia Papayannopoulou; David W Russell
Journal:  Cell Stem Cell       Date:  2012-10-18       Impact factor: 24.633

Review 5.  Metabolism and possible health effects of aluminum.

Authors:  P O Ganrot
Journal:  Environ Health Perspect       Date:  1986-03       Impact factor: 9.031
  5 in total

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