Literature DB >> 6154569

Audiogenic seizures and cochlear damage in rats after perinatal antithyroid treatment.

L Van Middlesworth, C H Norris.   

Abstract

The feeding of goitrogens during pregnancy and lactation causes the offspring of rats to be partially deaf and persistently sensitive to audiogenic seizures. The most potent goitrogen, propylthiouracil, caused severe dysfunction and disorganization of the organ of Corti. Adult seizure-susceptible rats showed increased sensitivity to audiogenic seizures when they were fed propylthiouracil.

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Year:  1980        PMID： 6154569     DOI： 10.1210/endo-106-6-1686

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  10 in total

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