A comparative investigation of the generation of specific T cell-helper function induced by Streptococcus mutans in monkeys and mice.

Antigen-specific helper cells were induced in vitro in monkeys and mice by using an antigen preparation from Streptococcus mutans. These helper cells were T cells on the basis of their sensitivity to anti-Thy. I and complement, and were not retained on nylon wool. Upon further in vitro culture the helper cells release mediators of help, "helper factor" in the supernatant. The release of helper factor as well as its augmentation of the immune response was antigen specific. Monkey and murine helper factors were similar in their induction, function, and specificity.