Literature DB >> 6153986

Distribution of substance P in the rat gastrointestinal tract--lack of effect of capsaicin pretreatment.

P Holzer, R Gamse, F Lembeck.   

Abstract

A new method for extraction of immunoreactive substance P (I-SP) from rat intestine including pulverization of tissue frozen in liquid nitrogen and extraction with acid acetone is described. Using this method, amounts of I-SP in the rat intestine were found to be higher than previously reported. The highest concentrations of I-SP were found in the small intestine. Capsaicin pretreatment of newborn or adult rats had no effect on intestinal I-SP concentrations indicating that intrinsic SP neurones are capsaicin-insensitive.

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Year:  1980        PMID： 6153986     DOI： 10.1016/0014-2999(80)90132-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  22 in total

1.  Effects of several denervation procedures on distribution of calcitonin gene-related peptide and substance P immunoreactive in rat stomach.

Authors:  T Suzuki; M Kagoshima; M Shibata; N Inaba; S Onodera; T Yamaura; H Shimada
Journal:  Dig Dis Sci       Date:  1997-06       Impact factor: 3.199

2.  Multiple motor pathways to single smooth muscle cells in the ferret trachea.

Authors:  H W Mitchell; R F Coburn
Journal:  J Physiol       Date:  1992-10       Impact factor: 5.182

3.  The effects of capsaicin upon electrogenic ion transport in rat descending colon.

Authors:  S Yarrow; J A Ferrar; H M Cox
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-11       Impact factor: 3.000

4.  Capsaicin enhances the non-adrenergic twitch response of rat vas deferens.

Authors:  H Moritoki; T Iwamoto; J Kanaya; Y Ishida; K Ando; K Kitagawa
Journal:  Br J Pharmacol       Date:  1987-10       Impact factor: 8.739

5.  Substance P in the argentaffin carcinoid of the caecum: biochemical and biological characterization.

Authors:  M Ratzenhofer; R Gamse; H Höfler; L Auböck; H Popper; P Pohl; F Lembeck
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1981

6.  Different contractile effects of substance P on the intestine of mammals.

Authors:  P Holzer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-09       Impact factor: 3.000

7.  Differential effects of capsaicin on the content of somatostatin, substance P, and neurotensin in the nervous system of the rat.

Authors:  R Gamse; S E Leeman; P Holzer; F Lembeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-09       Impact factor: 3.000

8.  Visceral pain reflex after pretreatment with capsaicin and morphine.

Authors:  F Lembeck; G Skofitsch
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-11       Impact factor: 3.000

9.  Substance P immunoreactive neurons following neonatal administration of capsaicin.

Authors:  A C Cuello; R Gamse; P Holzer; F Lembeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-01       Impact factor: 3.000

10.  Possible involvement of capsaicin-sensitive sensory nerves in the regulation of intestinal blood flow in the dog.

Authors:  Z Rózsa; G Jancsó; V Varró
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-07       Impact factor: 3.000
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