Literature DB >> 6153980

Immunological cross-reactivity of multiplication-stimulating activity polypeptides.

A C Moses, S P Nissley, P A Short, M M Rechler.   

Abstract

The immunoreactivity of the multiple species of multiplication-stimulating activity (MSA) purified from medium conditioned by a rat liver cell line (BRL-3A) has been examined. Antibodies were raised in rabbits following immunization with MSA II polypeptides. Subpopulations of antibodies were purified from one antiserum using DEAE-cellulose chromatography. One antibody subpopulation recognized common antigenic determinants on MSA I and MSA II polypeptides; whereas a second antibody subpopulation recognized common determinants on MSA I, II, and III polypeptides. In a radioimmunoassay utilizing 125I-MSA III-2 and a purified antibody subpopulation, the human somatomedins (somatomedin A, insulin-like growth factor I and II) showed weak, but significant cross-reactivity: insulin-like growth factor II was 10% as potent as MSA II. By contrast, somatomedin partially purified from rat serum, insulin, growth hormone, epidermal growth factor, nerve factor, and fibroblast growth factor, showed no reactivity in the radioimmunoassay.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6153980     DOI： 10.1111/j.1432-1033.1980.tb04326.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  11 in total

Review 1.  Molecular biology of the insulin-like growth factors. Relevance to nervous system function.

Authors:  J E Hepler; P K Lund
Journal:  Mol Neurobiol       Date:  1990 Spring-Summer       Impact factor: 5.590

2.  Demonstration of the production and physiological role of insulin-like growth factor II in rat thyroid follicular cells in culture.

Authors:  R M Maciel; A C Moses; G Villone; D Tramontano; S H Ingbar
Journal:  J Clin Invest       Date:  1988-11       Impact factor: 14.808

3.  Human alveolar macrophage growth factor for fibroblasts. Regulation and partial characterization.

Authors:  P B Bitterman; S I Rennard; G W Hunninghake; R G Crystal
Journal:  J Clin Invest       Date:  1982-10       Impact factor: 14.808

4.  Insulin, insulin-like growth factor II, and nerve growth factor effects on tubulin mRNA levels and neurite formation.

Authors:  J F Mill; M V Chao; D N Ishii
Journal:  Proc Natl Acad Sci U S A       Date:  1985-10       Impact factor: 11.205

5.  Differential expression of insulin-like growth factors I and II (IGF I and II), mRNA, peptide and binding protein 1 during mouse palate development: comparison with TGF beta peptide distribution.

Authors:  M W Ferguson; P M Sharpe; B L Thomas; F Beck
Journal:  J Anat       Date:  1992-10       Impact factor: 2.610

6.  Mechanisms of pulmonary fibrosis. Spontaneous release of the alveolar macrophage-derived growth factor in the interstitial lung disorders.

Authors:  P B Bitterman; S Adelberg; R G Crystal
Journal:  J Clin Invest       Date:  1983-11       Impact factor: 14.808

7.  Placental lactogen administration reverses the effect of low-protein diet on maternal and fetal serum somatomedin levels in the pregnant rat.

Authors:  S J Pilistine; A C Moses; H N Munro
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

8.  Receptors for insulinlike growth factor I are defective in fibroblasts cultured from a patient with leprechaunism.

Authors:  E E Van Obberghen-Schilling; M M Rechler; J A Romanus; A B Knight; S P Nissley; R E Humbel
Journal:  J Clin Invest       Date:  1981-11       Impact factor: 14.808

9.  Increased levels of multiplication-stimulating activity, an insulin-like growth factor, in fetal rat serum.

Authors:  A C Moses; S P Nissley; P A Short; M M Rechler; R M White; A B Knight; O Z Higa
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

10.  Developmental pattern of a serum binding protein for multiplication stimulating activity in the rat.

Authors:  R M White; S P Nissley; P A Short; M M Rechler; I Fennoy
Journal:  J Clin Invest       Date:  1982-06       Impact factor: 14.808
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.