Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Synthesis and mode(s) of action of a new series of imide derivatives of 3-nitro-1,8 naphthalic acid.

Literature DB >> 6153938

Synthesis and mode(s) of action of a new series of imide derivatives of 3-nitro-1,8 naphthalic acid.

M F Braña, J M Castellano, C M Roldán, A Santos, D Vázquez, A Jiménez.

Abstract

Four new imide derivatives of 3-nitro-1,8-naphthalic acid have been synthesised. The compounds show strong cytostatic activity against both HeLa and KB cells and are moderately toxic towards both mice and rats (LD50 above 4 mg/kg IP). Two of the most active compounds, M-4212 and M-12210, prevented the development of mouse Ehrlich ascites and rat Yoshida carcinoma. All these drugs block cell growth by inhibiting the synthesis of both DNA and RNA. In particular, both M-4212 and M-12210 raise the melting point of double-stranded DNA.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1980 PMID： 6153938 DOI： 10.1007/BF00255461

Source DB: PubMed Journal: Cancer Chemother Pharmacol ISSN： 0344-5704 Impact factor: 3.333

5 in total

1. TUMOR INHIBITORS. I. ARISTOLOCHIC ACID, THE ACTIVE PRINCIPLE OF ARISTOLOCHIA INDICA.

Authors: S M KUPCHAN; R W DOSKOTCH
Journal: J Med Pharm Chem Date: 1962-05

2. Inhibitors of protein synthesis in eukarytic cells. Comparative effects of some amaryllidaceae alkaloids.

Authors: A Jimenez; A Santos; G Alonso; D Vazquez
Journal: Biochim Biophys Acta Date: 1976-03-17

3. Influence of tilorone and cogeners on the secondary structure and template activity of DNA.

Authors: P Chandra; M Woltersdorf
Journal: FEBS Lett Date: 1974-04-15 Impact factor: 4.124

Review 4. Inhibitors of protein synthesis.

Authors: D Vazquez
Journal: FEBS Lett Date: 1974-03-23 Impact factor: 4.124

5. Experimental therapeutic investigations with 1-(morpholinomethyl)-4-phthalimido-piperidindione-2,6 on dimethylbenzanthracene-induced tumors of Sprague-Dawley rats.

Authors: H Mückter; E Frankus; E Moré
Journal: Cancer Res Date: 1969-06 Impact factor: 12.701

5 in total

28 in total

1. Synthesis and photophysical characterizations of thermal-stable naphthalene benzimidazoles.

Authors: Sule Erten-Ela; Serdar Ozcelik; Esin Eren
Journal: J Fluoresc Date: 2011-01-29 Impact factor: 2.217

2. Computer simulation of the binding of amonafide and azonafide to DNA.

Authors: S Bear; W A Remers
Journal: J Comput Aided Mol Des Date: 1996-04 Impact factor: 3.686

3. Synthesis and Photophysical Studies on Naphthalimide Derived Fluorophores as Markers in Drug Delivery.

Authors: Nidhi Singh; Ritika Srivastava; Anuradha Singh; Ramendra K Singh
Journal: J Fluoresc Date: 2016-05-26 Impact factor: 2.217

4. Design, Synthesis, and Evaluation of Novel 3-Carboranyl-1,8-Naphthalimide Derivatives as Potential Anticancer Agents.

Authors: Sebastian Rykowski; Dorota Gurda-Woźna; Marta Orlicka-Płocka; Agnieszka Fedoruk-Wyszomirska; Małgorzata Giel-Pietraszuk; Eliza Wyszko; Aleksandra Kowalczyk; Paweł Stączek; Andrzej Bak; Agnieszka Kiliszek; Wojciech Rypniewski; Agnieszka B Olejniczak
Journal: Int J Mol Sci Date: 2021-03-09 Impact factor: 5.923

Synthesis and mode(s) of action of a new series of imide derivatives of 3-nitro-1,8 naphthalic acid.

1. TUMOR INHIBITORS. I. ARISTOLOCHIC ACID, THE ACTIVE PRINCIPLE OF ARISTOLOCHIA INDICA.

2. Inhibitors of protein synthesis in eukarytic cells. Comparative effects of some amaryllidaceae alkaloids.

3. Influence of tilorone and cogeners on the secondary structure and template activity of DNA.

Review 4. Inhibitors of protein synthesis.

5. Experimental therapeutic investigations with 1-(morpholinomethyl)-4-phthalimido-piperidindione-2,6 on dimethylbenzanthracene-induced tumors of Sprague-Dawley rats.

1. Synthesis and photophysical characterizations of thermal-stable naphthalene benzimidazoles.

2. Computer simulation of the binding of amonafide and azonafide to DNA.

3. Synthesis and Photophysical Studies on Naphthalimide Derived Fluorophores as Markers in Drug Delivery.

4. Design, Synthesis, and Evaluation of Novel 3-Carboranyl-1,8-Naphthalimide Derivatives as Potential Anticancer Agents.

5. Effects of benzoylphenyl ureas on growth of B16 melanoma cells in vitro and in vivo.

6. Imide derivatives of 3-nitro-1.8-naphthalic acid: their inhibitory activity against DNA viruses.

7. Phase I study of mitonafide in 120 hour continuous infusion in non-small cell lung cancer.

8. Effect of mitonafide analogs on topoisomerase II of Leishmania chagasi.

9. In vitro activity of amonafide against primary human tumors compared with the activity of standard agents.

10. Phase II evaluation of amonafide in renal cell carcinoma. A Southwest Oncology Group study.