Literature DB >> 6153680

Participation of lymphocyte activating factor (Interleukin 1) in the induction of cytotoxic T cell responses.

W L Farrar, S B Mizel, J J Farrar.   

Abstract

The initiation of murine alloantigen-specific cytotoxic T cell responses is macrophage dependent. The requirement for macrophages can be replaced in macrophage-depleted cytotoxic T lymphocyte assay by a soluble factor released from phorbol myristic acetate-stimulated mouse peritoneal adherent cells or P388D1 macrophage tumor cells. On the basis of the cell of origin, m.w. (15,000), and elution profiles on DEAE cellulose and polyacrylamide gels, this macrophage-replacing factor for T cell-mediated cytotoxicity was identical to lymphocyte activating factor (LAF). The stimulatory effect of LAF was totally dependent on the presence of the priming alloantigen. The results presented in this report support the hypothesis that macrophage-mediated antigen-induced T cell activation is dependent on two signals, antigen and LAF.

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Year:  1980        PMID： 6153680

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  25 in total

1.  Interleukin-1 and -2 in sera of patients with chronic hepatitis (type B).

Authors:  T Ozeki; K Imanishi; H Unoki; K Funakoshi; Y Kiya
Journal:  Int J Exp Pathol       Date:  1990-12       Impact factor: 1.925

2.  Fibroblast interleukin 1 beta: synergistic stimulation by recombinant interleukin 1 and tumor necrosis factor and posttranscriptional regulation.

Authors:  J A Elias; M M Reynolds; R M Kotloff; J A Kern
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

3.  Radiosensitivity of isolated subsets of human lymphocytes (E+, OKT4+, OKT8+): protective role of monocytes and monokines.

Authors:  I Manori; A Kushilevsky; S Segal; Y Weinstein
Journal:  Clin Exp Immunol       Date:  1984-11       Impact factor: 4.330

Review 4.  Macrophages and antitumor reactions.

Authors:  W Den Otter; H F Dullens; R A De Weger
Journal:  Cancer Immunol Immunother       Date:  1983       Impact factor: 6.968

5.  Interaction between MHC-encoded products and cloned T cells. II. Analyses of physiological requirements indicate two different pathways of stimulation by class I alloantigens.

Authors:  F Albert; C Boyer; M Buferne; A M Schmitt-Verhulst
Journal:  Immunogenetics       Date:  1984       Impact factor: 2.846

6.  Report of a phase I evaluation of dose and schedule of interleukin-1 alpha and cyclophosphamide in patients with advanced tumors: An Eastern Cooperative Oncology Group study (PX990) and review of IL-1-based studies of hematopoietic reconstitution.

Authors:  Janice P Dutcher; Donna Neuberg; Michael B Atkins; William J Tester; Scott Wadler; James A Stewart; Abraham Chachoua; Lynn M Schuchter
Journal:  J Interferon Cytokine Res       Date:  2014-01-16       Impact factor: 2.607

7.  Role of Ia antigen expression and secretory function of accessory cells in the induction of cytotoxic T lymphocyte responses against herpes simplex virus.

Authors:  D S Schmid; H S Larsen; B T Rouse
Journal:  Infect Immun       Date:  1982-09       Impact factor: 3.441

8.  Demonstration of interleukin 1 activity in apparently homogeneous specimens of the pI 5 form of rabbit endogenous pyrogen.

Authors:  D F Hanson; P A Murphy
Journal:  Infect Immun       Date:  1984-08       Impact factor: 3.441

9.  Antigen-specific primary cytotoxic T lymphocyte (CTL) responses in acquired immune deficiency syndrome (AIDS) and AIDS-related complexes (ARC).

Authors:  B Sharma; S Gupta
Journal:  Clin Exp Immunol       Date:  1985-11       Impact factor: 4.330

10.  Lectin-induced cytotoxic activity in spleen cells from young and old mice. Age-related changes in types of effector cells, lymphokine production and response.

Authors:  R K Saxena; Q B Saxena; W H Adler
Journal:  Immunology       Date:  1988-07       Impact factor: 7.397
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