Literature DB >> 6153544

Enhancement of rat brain metabolism of a tryptophan load by chronic ethanol administration.

A A Badawy, M Evans, N F Punjani.   

Abstract

We have previously shown that chronic ethanol administration enhances brain 5-hydroxytryptamine synthesis by increasing the availability of circulating tryptophan to the brain secondary to the decreased liver tryptophan pyrrolase activity. We now find that ethanol enhances the brain metabolism of a tryptophan load by the same mechanism. The results are discussed in relation to ethanol preference and the need for further clinical work on the effects of alcoholism on tryptophan metabolism.

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Year:  1980        PMID： 6153544      PMCID： PMC2044076          DOI： 10.1111/j.1476-5381.1980.tb10694.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  7 in total

1.  Urinary excretion of 5-HIAA in chronic alcoholism.

Authors:  G E MURPHY; S B GUZE; L J KING
Journal:  JAMA       Date:  1962-11-03       Impact factor: 56.272

2.  Evidence for a defect in tryptophan metabolism in chronic alcoholism.

Authors:  R E OLSON; D GURSEY; J W VESTER
Journal:  N Engl J Med       Date:  1960-12-08       Impact factor: 91.245

3.  Tryptophan loading: consequent effects on the synthesis of kynurenine and 5-hydroxyindoles in rat brain.

Authors:  E M Gál; R B Young; A D Sherman
Journal:  J Neurochem       Date:  1978-07       Impact factor: 5.372

4.  Pyridoxine deficiency and tryptophan metabolism in chronic alcoholics.

Authors:  M P Walsh; P J Howorth; V Marks
Journal:  Am J Clin Nutr       Date:  1966-12       Impact factor: 7.045

5.  Enhancement of rat brain tryptophan metabolism by chronic ethanol administration and possible involvement of decreased liver tryptophan pyrrolase activity.

Authors:  A A Badawy; N F Punjani; M Evans
Journal:  Biochem J       Date:  1979-03-15       Impact factor: 3.857

6.  The metabolism of a tryptophan load in rat brain and liver: the influence of L-alpha-methyldopa hydrazine (MK-486, Carbidopa).

Authors:  M H Joseph; D L Hall-Tipping
Journal:  Biochem Soc Trans       Date:  1978       Impact factor: 5.407

7.  The influence of L-tryptophan and monoamine oxidase inhibitors on catecholamine metabolism in rat brain.

Authors:  D Eccleston; N Nicolaou
Journal:  Br J Pharmacol       Date:  1978-11       Impact factor: 8.739
  7 in total
  2 in total

1.  Effects of chronic ethanol administration on serotonin metabolism in the various regions of the rat brain.

Authors:  I T Uzbay; S E Usanmaz; E S Akarsu
Journal:  Neurochem Res       Date:  2000-02       Impact factor: 3.996

2.  Substrate induced alterations in tryptophan pyrrolase activity in two mouse strains.

Authors:  R I Peters; D C Frost; M L Evans
Journal:  Experientia       Date:  1982-05-15
  2 in total

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