Literature DB >> 6152348

Benzodiazepines and GABAergic regulation of nigrostriatal neurons: lack of tolerance.

P L Wood, P Etienne, S Lal, N P Nair.   

Abstract

Decreases of 40 to 50% in striatal dopamine release by diazepam in doses above 5 mg/kg were elicited. Similar actions were observed with clonazepam and nitrazepam. No tolerance to these actions was evident after 3 weeks of chronic treatment. These data are consistent with a potent inhibitory GABAergic regulation of nigrostriatal dopaminergic neurons.

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Year:  1984        PMID: 6152348     DOI: 10.1016/0278-5846(84)90058-7

Source DB:  PubMed          Journal:  Prog Neuropsychopharmacol Biol Psychiatry        ISSN: 0278-5846            Impact factor:   5.067


  2 in total

1.  Evidence for a role for dopamine in the diazepam locomotor stimulating effect.

Authors:  B Söderpalm; L Svensson; P Hulthe; K Johannessen; J A Engel
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

2.  Benzodiazepine-induced decreases in extracellular concentrations of dopamine in the nucleus accumbens after acute and repeated administration.

Authors:  J M Finlay; G Damsma; H C Fibiger
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

  2 in total

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