Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Dose-response studies with pancuronium, vecuronium and their combination.

Literature DB >> 6152177

Dose-response studies with pancuronium, vecuronium and their combination.

C J Ferres, R K Mirakhur, S K Pandit, R S Clarke, F M Gibson.

Abstract

Pancuronium, vecuronium and a combination of these were administered in an incremental fashion to study any potentiation of effect with the combination of the two relaxants. The ED95 (dose producing a 95% block) of the combination was 29 micrograms kg-1 for each component in comparison to 57 micrograms kg-1 for vecuronium and 59 micrograms kg-1 for pancuronium. The dose-response curves for the three groups did not differ from each other and no potentiation was demonstrated.

Entities: Chemical

Mesh：

Substances：

Year: 1984 PMID： 6152177 PMCID： PMC1463666 DOI： 10.1111/j.1365-2125.1984.tb02568.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

7 in total

1. Some synergistic effects of d-tubocurarine and gallamine.

Authors: K C Wong; J R Jones
Journal: Anesth Analg Date: 1971 Mar-Apr Impact factor: 5.108

2. The emergence of ORG NC 45, 1- [2 beta,3 alpha,5 alpha,16 beta,17 beta)-3, 17-bis(acetyloxy)-2-(1-piperidinyl)-androstan-16-yl]-1-methylpiperidinium bromide, from the pancuronium series.

Authors: D S Savage; T Sleigh; I Carlyle
Journal: Br J Anaesth Date: 1980 Impact factor: 9.166

3. The neuromuscular blocking action of ORG NC 45, a new pancuronium derivative, in anaesthetized patients. A pilot study.

Authors: S Agoston; P Salt; D Newton; A Bencini; P Boomsma; W Erdmann
Journal: Br J Anaesth Date: 1980 Impact factor: 9.166

2 in total

1. Interactions between ORG9426 and other non-depolarizing neuromuscular blocking agents in rats in vivo.

Authors: K Watanabe
Journal: J Anesth Date: 1992-07 Impact factor: 2.078

2. Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors.

Authors: Man Liu; James P Dilger
Journal: Anesth Analg Date: 2008-08 Impact factor: 5.108

2 in total

Dose-response studies with pancuronium, vecuronium and their combination.

1. Some synergistic effects of d-tubocurarine and gallamine.

2. The emergence of ORG NC 45, 1- [2 beta,3 alpha,5 alpha,16 beta,17 beta)-3, 17-bis(acetyloxy)-2-(1-piperidinyl)-androstan-16-yl]-1-methylpiperidinium bromide, from the pancuronium series.

3. The neuromuscular blocking action of ORG NC 45, a new pancuronium derivative, in anaesthetized patients. A pilot study.

4. Combination of pancuronium and metocurine: neuromuscular and hemodynamic advantages over pancuronium alone.

5. The interaction between d-tubocurarine and gallamine during halothane anaesthesia.

6. Time course of muscle relaxation with a combination of pancuronium and tubocurarine.

7. Competitive nonspecific binding does not explain the potentiating effects of muscle relaxant combinations.

1. Interactions between ORG9426 and other non-depolarizing neuromuscular blocking agents in rats in vivo.

2. Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors.