Literature DB >> 6151596

Excitatory amino acid receptor interactions of a novel alpha-phosphinic acid analogue of alpha-methylaspartic acid.

L A Cates, V S Li, Z S Hu, J Lehmann, J T Coyle, J W Ferkany.   

Abstract

An alpha-phosphino analogue of alpha-methylaspartate has been synthesized. The compound may not interact with excitatory amino acid receptors directly, as assessed by direct in vitro radioreceptor binding methods; however, it possesses weak anticonvulsant activity and exhibits an excitant action in vitro that is apparently not mediated by a N-methyl-D-aspartate receptor.

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Year:  1984        PMID: 6151596     DOI: 10.1002/jps.2600731115

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN: 0022-3549            Impact factor:   3.534


  1 in total

1.  Phosphinic Acid analogues of methylaspartic and methylglutamic acids as antibacterials.

Authors:  L A Cates; V S Li
Journal:  Pharm Res       Date:  1985-05       Impact factor: 4.200

  1 in total

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