Interaction of glucocorticoids in stimulation of liver tyrosine aminotransferase and tryptophan pyrrolase by estrogen in female rats.

Bilateral adrenalectomy inhibited the increase in liver tyrosine aminotransferase and tryptophan pyrrolase activity after s.c. administration of cca 50 micrograms 17-beta-estradiol (Agofollin SPOFA, Praha) per 1 kg body weight daily for 14 days. Moreover, the authors describe the restitution of the estrogen effect by peroral dexamethasone intake via the drinking saline offered to the animals during the period of Agofollin treatment. In rats substituted in this way the resulting enzyme activities even exceeded those caused by dexamethasone alone.