Influence of indometacin and acetylsalicylic acid on the therapeutic effectiveness of talinolol in patients with essential hypertension.

Clinical-pharmacological investigations on interactions between cyclo-oxygenase inhibitors and beta-adrenoceptor blocking agents continuing, indometacin and acetylsalicylic acid (ASA) were added to a monotherapy of talinolol in two groups of hypertensive outpatients. Both added drugs reduced slightly the blood pressure lowering effect of talinolol, but did not alter its negative chronotropic effect. Indometacin abolished a talinolol-induced increase in serum triglycerides and caused a small decrease in serum cholesterol. ASA diminished slightly blood glucose. Probably the observed interactions and side effects are not important practically.