Gap junctions increase the sensitivity of tissue cells to exogenous electric fields.

Cells coupled by gap junctions will react as a single unit to an applied electric field. In a given field, the hyperpolarization and depolarization of cell membranes at the ends of an electrotonically coupled tissue are increases by a factor of 10-100 over single, uncoupled cells. Gap junctional coupling therefore increases the likelihood that cells are influenced by the weak electric fields which are commonly found in developing and regenerating tissues.